Intense Exercise Induces Mitochondrial Dysfunction in Mice Brain

被引：0
作者：
Aderbal S. Aguiar
Talita Tuon
Cléber A. Pinho
Luciano A. Silva
Ana C. Andreazza
Flávio Kapczinski
João Quevedo
Emílio L. Streck
Ricardo A. Pinho
机构：
[1] Universidade do Extremo Sul Catarinense,Laboratory of Exercise Physiology and Biochemistry, Post
[2] Universidade Federal do Rio Grande do Sul,graduation Program in Health Sciences
[3] Hospital de Clinicas de Porto Alegre,Department of Biochemistry
[4] Universidade do Extremo Sul Catarinense,Bipolar Disorders Program, Research Center
[5] Universidade do Extremo Sul Catarinense,Laboratory of Neurosciences, Post
来源：
Neurochemical Research | 2008年 / 33卷
关键词：
Cytochrome c oxidase; Citrate synthase; Oxidative stress; BDNF; Physical exercise; Brain;
D O I：
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中图分类号：
学科分类号：
摘要：
There are conflicts between the effects of free radical over-production induced by exercise on neurotrophins and brain oxidative metabolism. The objective of this study was to investigate the effects of intense physical training on brain-derived neurotrophic factor (BDNF) levels, COX activity, and lipoperoxidation levels in mice brain cortex. Twenty-seven adult male CF1 mice were assigned to three groups: control untrained, intermittent treadmill exercise (3 × 15 min/day) and continuous treadmill exercise (45 min/day). Training significantly (P < 0.05) increased citrate synthase activity when compared to untrained control. Blood lactate levels classified the exercise as high intensity. The intermittent training significantly (P < 0.05) reduced in 6.5% the brain cortex COX activity when compared to the control group. BDNF levels significantly (P < 0.05) decreased in both exercise groups. Besides, continuous and intermittent exercise groups significantly (P < 0.05) increased thiobarbituric acid reactive species levels in the brain cortex. In summary, intense exercise promoted brain mitochondrial dysfunction due to decreased BDNF levels in the frontal cortex of mice.
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页码：51 / 58
页数：7
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