Plasmalemmal vacuolar-type H+-ATPase in cancer biology

被引：0
作者：
Souad R. Sennoune
Defeng Luo
Raul Martinez-Zaguilán
机构：
[1] Texas Tech University,Department of Physiology
[2] Health Sciences Center,Southwest Cancer Center
[3] Texas Tech University,undefined
[4] Health Sciences Center,undefined
来源：
Cell Biochemistry and Biophysics | 2004年 / 40卷
关键词：
V-ATPase; F-ATPase; organelle; plasma membrane; tumor; invasion; metastasis; apoptosis;
D O I：
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中图分类号：
学科分类号：
摘要：
Vacuolar-type H+-adenosine triphosphatase (V-ATPase) is one of the most fundamental enzymes in nature. V-ATPases are responsible for the regulation of proton concentration in the intracellular acidic compartments. It has similar structure with the mitochondrial F0F1-ATP synthase (F-ATPase).† The V-ATPases are composed of multiple subunits and have various physiological functions, including membrane and organelle protein sorting, neurotransmitter uptake, cellular degradative processes, and cytosolic pH regulation. The V-ATPases have been involved in multidrug resistance. Recently, plasma membrane V-ATPases have been involved in regulation of extracellular acidity, essential for cellular invasiveness and proliferation in tumor metastasis. The current knowledge regarding the structure and function of V-ATPase and its role in cancer biology is discussed.
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页码：185 / 206
页数：21
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