Photophysical and Biological Studies with Organometallic Ruthenium Complexes of Selenodiazole Ligands

被引：0
作者：
Raja Mitra
V. S. Sridevi
Kumaravel Somasundaram
Ashoka G. Samuelson
机构：
[1] Indian Institute of Science,Department of Inorganic and Physical Chemistry
[2] Indian Institute of Science,Department of Molecular and Cellular Biology
[3] Universität Duisburg-Essen,Institut für Organische Chemie
来源：
Proceedings of the National Academy of Sciences, India Section A: Physical Sciences | 2016年 / 86卷
关键词：
Piazselenol; Half-sandwich; Ligand dissociation; Imaging agents; Anticancer;
D O I：
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学科分类号：
摘要：
Substituted selenodiazoles (piazselenols) were used as ligands to synthesize organometallic ruthenium(II) piano-stool complexes using the precursors ([η6-cymene)RuX2 (where x = Cl, Br and I). Analytical data suggested that two (η6-cymene)Ru motifs were present per ligand in the solid state. However, 1H and 77Se NMR in DMSO solution confirmed the dissociation of the selenodiazole ligand from the ruthenium center. Interestingly, selenodiazole with naphthalene substitutes possess excellent photophysical properties. It showed strong red fluorescence (576 nm) when excited at visible region (488 nm) and was found suitable for use as an imaging agent in HCT 116 cells. Among all ligands examined, only the nitro substituted selenodiazole showed potent anticancer activity against the A2780 cell line.
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页码：511 / 520
页数：9
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