APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly

被引：0
作者：
Anniina Snellman
Laura L. Ekblad
Jouni Tuisku
Mikko Koivumäki
Nicholas J. Ashton
Juan Lantero-Rodriguez
Thomas K. Karikari
Semi Helin
Marco Bucci
Eliisa Löyttyniemi
Riitta Parkkola
Mira Karrasch
Michael Schöll
Henrik Zetterberg
Kaj Blennow
Juha O. Rinne
机构：
[1] University of Turku,Turku PET Centre
[2] Turku University Hospital,Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology
[3] the Sahlgrenska Academy at the University of Gothenburg,Centre for Age
[4] Stavanger University Hospital,Related Medicine
[5] Maurice Wohl Clinical Neuroscience Institute,Department of Old Age Psychiatry
[6] King’s College London,Department of Psychiatry
[7] NIHR Biomedical Research Centre for Mental Health & Biomedical Research Unit for Dementia at South London & Maudsley NHS Foundation,Theme Inflammation and Aging
[8] University of Pittsburgh,Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society
[9] Karolinska University Hospital,Department of Biostatistics
[10] Karolinska Institutet,Department of Radiology
[11] University of Turku,Department of Psychology
[12] Turku University Hospital,Department of Neurodegenerative Disease
[13] University of Turku,Wallenberg Centre for Molecular and Translational Medicine
[14] Åbo Akademi University,Clinical Neurochemistry Laboratory
[15] UCL Queen Square Institute of Neurology,InFLAMES Research Flagship Center
[16] University College London,undefined
[17] University of Gothenburg,undefined
[18] Sahlgrenska University Hospital,undefined
[19] UK Dementia Research Institute at UCL,undefined
[20] Hong Kong Center for Neurodegenerative Diseases,undefined
[21] University of Turku,undefined
来源：
Alzheimer's Research & Therapy | / 15卷
关键词：
Alzheimer’s disease; Microglia; Astrocytes; Beta-amyloid; PET; TSPO; Apolipoprotein E; GFAP; Biomarker;
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