Features of Remyelination after Transplantation of Olfactory Ensheathing Cells with Neurotrophic Factors into Spinal Cord Cysts

被引：0

作者：

Stepanova, O. V. ^{[1
,5
]}

Fursa, G. A. ^{[1
]}

Karsuntseva, E. K. ^{[1
]}

Andretsova, S. S. ^{[1
,4
]}

Chadin, A. V. ^{[1
]}

Voronova, A. D. ^{[1
]}

Shishkina, V. S. ^{[1
]}

Semkina, A. S. ^{[1
,2
]}

Reshetov, I. V. ^{[3
]}

Chekhonin, V. P. ^{[1
,2
]}

机构：

[1] Minist Hlth Russian Federat, VP Serbsky Natl Med Res Ctr Psychiat & Narcol, Moscow, Russia

[2] Pirogov Russian Natl Res Med Univ, Minist Hlth Russian Federat, Moscow, Russia

[3] Sechenov Univ, IM Sechenov Moscow State Med Univ 1, Univ Clin Hosp, Minist Hlth Russian Federat, Moscow, Russia

[4] Moscow MV Lomonosov State Univ, Moscow, Russia

[5] Minist Hlth Russian Federat, EI Chazov Natl Med Res Ctr Cardiol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2024年 / 176卷 / 05期

关键词：

neurotrophin-3 (NT-3); brain-derived neurotrophic factor (BDNF); olfactory ensheathing cells; remyelination; spinal cord cysts; SCHWANN-CELLS; INJURY; REGENERATION; MYELINATION; SURVIVAL; DOMAIN;

D O I：

10.1007/s10517-024-06088-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This paper shows for the first time that co-transplantation of human olfactory ensheathing cells with neurotrophin-3 into spinal cord cysts is more effective for activation of remyelination than transplantation of cells with brain-derived neurotrophic factor and a combination of these two factors. The studied neurotrophic factors do not affect proliferation and migration of ensheathing cells in vitro. It can be concluded that the maximum improvement of motor function in rats receiving ensheathing cells with neurotrophin-3 is largely determined by activation of remyelination.

引用

页码：666 / 671

页数：6

共 31 条

[1] Remyelination of spinal cord axons by olfactory ensheathing cells and Schwann cells derived from a transgenic rat expressing alkaline phosphatase marker gene
Akiyama, Yukinori
Lankford, Karen
Radtke, Christine
Greer, Charles A.
Kocsis, Jeffery D.
[J]. NEURON GLIA BIOLOGY, 2004, 1 : 47 - 55
[2] Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms
Alizadeh, Arsalan
Dyck, Scott Matthew
Karimi-Abdolrezaee, Soheila
[J]. FRONTIERS IN NEUROLOGY, 2019, 10
[3] Neurotrophin 3 promotes purification and proliferation of olfactory ensheathing cells from human nose
Bianco, JI
Perry, C
Harkin, DG
Mackay-Sim, A
Féron, F
[J]. GLIA, 2004, 45 (02) : 111 - 123
[4] Translational potential of olfactory mucosa for the study of neuropsychiatric illness
Borgmann-Winter, K.
Willard, S. L.
Sinclair, D.
Mirza, N.
Turetsky, B.
Berretta, S.
Hahn, C-G
[J]. TRANSLATIONAL PSYCHIATRY, 2015, 5 : e527 - e527
[5] Bothwell M, 2014, Handb Exp Pharmacol, V220, P3, DOI 10.1007/978-3-642-45106-5_1
[6] NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes
Chan, JR
Watkins, TA
Cosgaya, JM
Zhang, CZ
Chen, L
Reichardt, LF
Shooter, EM
Barres, BA
[J]. NEURON, 2004, 43 (02) : 183 - 191
[7] Franklin Robin J M, 2003, Anat Rec B New Anat, V271, P71, DOI 10.1002/ar.b.10013
[8] Brain-derived neurotrophic factor applied to the motor cortex promotes sprouting of corticospinal fibers but not regeneration into a peripheral nerve transplant
Hiebert, GW
Khodarahmi, K
McGraw, J
Steeves, JD
Tetzlaff, W
[J]. JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 69 (02) : 160 - 168
[9] The culture of olfactory ensheathing cells (OECs)-a distinct glial cell type
Higginson, Jennifer R.
Barnett, Susan C.
[J]. EXPERIMENTAL NEUROLOGY, 2011, 229 (01) : 2 - 9
[10] Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury
Keefe, Kathleen M.
Sheikh, Imran S.
Smith, George M.
[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (03):

← 1 2 3 4 →