Six novel steroids from culture of basidiomycete Polyporus ellisii

被引：20

作者：

Shuang Wang

Ling Zhang

Liang-Yan Liu

Ze-Jun Dong

Zheng-Hui Li

Ji-Kai Liu

机构：

[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming

[2] University of Chinese Academy of Sciences, Beijing

来源：

Natural Products and Bioprospecting | 2012年 / 2卷 / 6期

关键词：

basidiomycete; cytotoxicity; ergosterol; Polyporus ellisii;

D O I：

10.1007/s13659-012-0058-4

中图分类号：

学科分类号：

摘要：

Investigation of the culture of basidiomycete Polyporus ellisii led to the isolation of a novel compound 3β,9α,15α-trihydroxy-(22E,24R)-10(5→4)-abeo-ergosta-6,8(14),22-trien-5-one (1) with a new 5/7/6/5 ring system of ergosterol skeleton. In addition, five new steroids, 5β,6β-epoxy-3β,7α,9α-trihydroxy-(22E,24R)-ergosta-8(14),22-dien-15-one (2), 5β,6β-epoxy-3β,7α-dihydroxy-(22E,24R)-ergosta-8(14),22-dien-15-one (3), 5α,6α-epoxy-3β,9α,15α-trihydroxy-(22E,24R)-ergosta-8(14),22-dien-7-one (4), 15α-acetoxy-(22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (5), 15β-methoxy-(22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (6), along with four known ergosterols (7–10), were obtained. All structures were elucidated based on 1D and 2D NMR spectral data. New compounds were evaluated for cytotoxicity against five human cancer cell lines, only compound 4 was found to exhibit a favorable cytotoxicity profile toward all tested tumor cell lines. Graphical abstract: [Figure not available: see fulltext.]. © 2012, The Author(s).

引用

页码：240 / 244

页数：4

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