Nasal administration of the neuroprotective candidate NeuroEPO to healthy volunteers: a randomized, parallel, open-label safety study

被引：0
|
作者：
Orestes Santos-Morales
Alina Díaz-Machado
Daise Jiménez-Rodríguez
Yaisel Pomares-Iturralde
Tatiana Festary-Casanovas
Carlos A. González-Delgado
Sonia Pérez-Rodríguez
Eulalia Alfonso-Muñoz
Carmen Viada-González
Patricia Piedra-Sierra
Idrian García-García
Daniel Amaro-González
Julio César García-Rodríguez
Iliana Sosa-Testé
Alicia Lagarto-Parra
Laura Barrero-Viera
Marlene David-Baldo
Maura Tamayo-Rodríguez
Ivonne Rivero-Vázquez
Gricel González-Gamiz
Alis Martín-Trujillo
Yasmila Rodríguez-Fernández
Ana Alfa Ledo-de la Luz
Maylén Álvarez-Delgado
Ivón Howland-Álvarez
Yolanda Cruz-Gómez
机构：
[1] NeuroEPO Research and Development Group,National Center for Toxicology
[2] Center of Molecular Immunology,undefined
[3] “Carlos J. Finlay” University Hospital,undefined
[4] Clinical Trials Group,undefined
[5] Research Direction,undefined
[6] Center for Drug Research and Development (CIDEM),undefined
来源：
BMC Neurology | / 17卷
关键词：
Non-hematopoietic recombinant erythropoietin; NeuroEPO; Stroke; Neurodegenerative diseases; Healthy volunteers; Safety; Hematopoietic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] An Open-Label, Randomized Bioavailability Study of Alternative Methods of Oral Administration of Naloxegol in Healthy Subjects
    Bui, Khanh
    Birmingham, Bruce
    Diva, Ulysses
    Berger, Bruce
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2017, 6 (04): : 420 - 427
  • [22] Pharmacokinetics and safety evaluation of oral Palonosetron in Chinese healthy volunteers: A phase 1, open-label, randomized, cross-over study
    Chen, Rui
    Wang, Hongyun
    Zhong, Wen
    Chessari, Salvatore
    Lanzarotti, Corinna
    Bernareggi, Alberto
    Hu, Pei
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 160
  • [23] Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of Intravenous Siponimod: A Randomized, Open-label Study in Healthy Subjects
    Shakeri-Nejad, Kasra
    Gardin, Anne
    Gray, Cathy
    Neelakantham, Srikanth
    Dumitras, Swati
    Legangneux, Eric
    CLINICAL THERAPEUTICS, 2020, 42 (01) : 175 - 195
  • [24] Pharmacokinetic properties of pravastatin in mexicans: An open-label study in healthy adult volunteers
    Escobar, Y
    Venturelli, CR
    Hoyo-Vadillo, C
    CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 2005, 66 (03): : 238 - 246
  • [25] Effects of ilaprazole on the steady-state pharmacodynamics of clopidogrel in healthy volunteers: An open-label randomized crossover study
    Ye, Zekang
    Chen, Pengsheng
    Tan, Chuchu
    Gong, Xiaoxuan
    Li, Ran
    Dong, Zhou
    Ullah, Inam
    Zhou, Chen
    Zhou, Sufeng
    Xie, Lijun
    Hou, Xuemei
    Han, Zhihui
    Gu, Qian
    Ma, Jiazheng
    Teng, Jianzhen
    Tang, Yingdan
    Zhang, Zhuanxia
    Hu, Haitang
    Zhuang, Quankun
    Chen, Juan
    Zhu, Bei
    Shao, Feng
    Li, Chunjian
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [26] An Open-Label, Randomized, 2-Way, Crossover Bioequivalence Study of Cefradine Capsules in Healthy Chinese Volunteers
    Lai, Xiuping
    Ye, Suiwen
    Chen, Liuhan
    Chen, Junyi
    Zhang, Nan
    Zhang, Yiwen
    Wu, Junyan
    Yao, Herui
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2021, 10 (12): : 1478 - 1484
  • [27] Bioequivalence study of oral pimavanserin capsule in healthy adult volunteers: Results from a randomized, crossover, open-label study
    Kumar, Sudershan
    Tiwari, Neeta
    Devkare, Prashant
    Bedi, Simrata
    Khuroo, Arshad
    Singh, Romi
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2023, 455
  • [28] Comparative crossover, randomized, open-label bioequivalence study on the bioequivalence of two formulations of thioctic acid in healthy volunteers
    Mignini, Fiorenzo
    Streccioni, Valentino
    Tomassoni, Daniele
    Traini, Enea
    Amenta, Francesco
    CLINICAL AND EXPERIMENTAL HYPERTENSION, 2007, 29 (08) : 575 - 586
  • [29] Pharmacokinetics and tolerability of intravenous posaconazole in healthy Chinese volunteers: a randomized, open-label and single-dose study
    Ji, Wei
    Zhao, Hengli
    Yang, Shaomei
    Wen, Qing
    He, Kun
    PHARMAZIE, 2020, 75 (10): : 491 - 493
  • [30] A Randomized, Open-Label, Crossover Study to Evaluate the Pharmacokinetics of Empagliflozin and Linagliptin After Coadministration in Healthy Male Volunteers
    Friedrich, Christian
    Metzmann, Katrin
    Rose, Peter
    Mattheus, Michaela
    Pinnetti, Sabine
    Woerle, Hans J.
    CLINICAL THERAPEUTICS, 2013, 35 (01) : A33 - A42
12345