A New Lipoxygenase Inhibitory Flavonoid from the Kino of Eucalyptus citriodora

被引：0
作者：
Shwu-Woan Lee
机构：
[1] Chia-Nan University of Pharmacy and Science,Department of Medicinal Chemistry
来源：
Chemistry of Natural Compounds | 2019年 / 55卷
关键词：
kino; lipoxygenase; flavonoid;
D O I：
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学科分类号：
摘要：
A new lipoxygenase inhibitory flavonoid, 8-[1-(p-hydroxyphenyl)ethyl]rhamnocitrin (1), together with four known compounds, cinnamic acid (2), p-coumaric acid (3), caffeic acid (4), and gallic acid (5), was isolated from the kino of Eucalyptus citriodora, and their structures were elucidated on the basis of spectroscopic methods including 2D NMR spectra. These compounds were tested for inhibitory activity against 15-lipoxygenase. Compound 1 showed stronger inhibitory activity (IC50 27.6 ± 0.7 μM) than the positive control quercetin (IC50 37.5 ± 0.8 μM).
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页码：18 / 20
页数：2
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