Role of endothelin-1 in lung disease

被引：0
作者：
Karen A Fagan
Ivan F McMurtry
David M Rodman
机构：
[1] University of Colorado Health Sciences Center,Assistant Professor of Medicine, Cardiovascular Pulmonary Research Laboratory, Division of Pulmonary Sciences and Critical Care Medicine
来源：
Respiratory Research | / 2卷
关键词：
asthma; endothelin; fibrosis; inflammation; pulmonary hypertension;
D O I：
暂无
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学科分类号：
摘要：
Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of the airways, pulmonary circulation, and inflammatory lung diseases, both acute and chronic. This review will focus on the biology of ET-1 and its role in lung disease.
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