Induced pluripotent stem cells: From derivation to application in biochemical and biomedical research

被引：0
|
作者：
E. V. Novosadova
I. A. Grivennikov
机构：
[1] Russian Academy of Sciences,Institute of Molecular Genetics
来源：
Biochemistry (Moscow) | 2014年 / 79卷
关键词：
induced pluripotent stem cells; embryonic stem cells; reprogramming; differentiation; transcriptional factors; cell therapy; human diseases; neurodegeneration;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This review considers different methods for obtaining induced pluripotent stem (iPS) cells and their use in biochemical and biomedical research. Some viral and nonviral methods for obtaining iPS cells are described. Basic factors involved in reprogramming are considered. It is also demonstrated that the most suitable source of iPS cells are skin fibroblasts. Properties of iPS cells and embryonic stem cells are compared, and some advantages of iPS cells for biological and biomedical investigations are emphasized. The possibilities for application of iPS cells in the development of cell models of some neurodegenerative diseases, drug screening, and cell therapy are also considered.
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页码：1425 / 1441
页数：16
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