Plasma and cerebrospinal fluid pharmacokinetics of the histone deacetylase inhibitor, belinostat (PXD101), in non-human primates

被引:0
作者
Katherine E. Warren
Cindy McCully
Henrik Dvinge
Jette Tjørnelund
Maxwell Sehested
Henri S. Lichenstein
Frank M. Balis
机构
[1] National Cancer Institute,
[2] Topotarget A/S,undefined
[3] Curagen Corporation,undefined
来源
Cancer Chemotherapy and Pharmacology | 2008年 / 62卷
关键词
Cerebrospinal fluid; Pharmacokinetics; Histone deacetylase; PXD101; Belinostat;
D O I
暂无
中图分类号
学科分类号
摘要
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页码:433 / 437
页数:4
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[1]  
Timmerman S(2001)Histone acetylation and disease Cell Mol Life Sci 8 728-736
[2]  
Lehrmann H(2002)Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation Adv Cancer Res 86 41-17179
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Polesskaya A(2003)Histone deacetylase in carcinogenesis and its inhibitors as anticancer agents J Biochem Mol Biol 36 110-3007
[4]  
Harel-Bellan A(1990)Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A J Biol Chem 265 17174-114
[5]  
Lehrmann H(1998)A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases Proc Natl Acad Sci USA 95 3003-81
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Pritchard L(2001)Histone deacetylase inhibitors, such as sodium butyrate and trichostatin A induce apoptosis through an increase of the bcl-2-related protein Bad Brain Tumor Pathol 18 109-728
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Kim D(2003)Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101 Mol Cancer Therap 2 721-2046
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