Validation of the WristOx 3100™ oximeter for the diagnosis of sleep apnea/hypopnea syndrome

To evaluate the diagnostic accuracy of the Nonin WristOx 3100 (TM) and its software (nVision 5.0) in patients with suspicion of sleep apnea/hypopnea syndrome (SAHS). All participants (168) had the oximetry and polysomnography simultaneously. The two recordings were interpreted blindly. The software calculated: adjusted O-2 desaturation index [ADI]-mean number of O-2 desaturation per hour of total recording analyzed time of a parts per thousand yenaEuro parts per thousand 2%, 3%, 4%, 5%, and 6% (ADI2, 3, 4, 5, and 6) and AT90-accumulated time at SO2 < 90%. The ADI2, 3, 4, 5, and 6 and the AT90 cutoff points that better discriminated between subjects with or without SAHS arose from the receiver operating characteristic curve analysis. The sensitivity (S), specificity (E), and positive and negative likelihood ratio (LR+, LR-) for the different thresholds for ADI were calculated. One hundred and fifty-four patients were included (119 men, mean age 51, median apnea/hypopnea index [AHI] 14, median body mass index [BMI] 28.3 kg/m(2)). The best cutoff points of ADI were: SAHS = AHI a parts per thousand yenaEuro parts per thousand 5: ADI2 > 19.3 (S 89%, E 94%, LR+ 15.5 LR- 0.11); SAHS =AHI a parts per thousand yenaEuro parts per thousand 10: ADI3 > 10.5 (S 88%, E 94%, LR+ 15 LR- 0.12); SAHS = AHI a parts per thousand yenaEuro parts per thousand 15: ADI3 > 13.4 (S 88%, E 90%, LR+ 8.9, LR- 0.14). AT90 had the lowest diagnosis accuracy. An ADI2 a parts per thousand currency signaEuro parts per thousand 12.2 excluded SAHS (AHI a parts per thousand yenaEuro parts per thousand 5 and 10; S 100%, LR- 0) and ADI3 > 4.3 (AHI a parts per thousand yenaEuro parts per thousand 5 and 10) or 32 (AHI a parts per thousand yenaEuro parts per thousand 15) confirmed SAHS (E 100%). A negative oximetry defined as ADI2 a parts per thousand currency signaEuro parts per thousand 12.2 excluded SAHS defined as AHI a parts per thousand yenaEuro parts per thousand 5 or 10 with a sensitivity and negative likelihood ratio of 100% and 0%, respectively. Furthermore, a positive oximetry defined as an ADI3 > 32 (SAHS = AHI a parts per thousand yenaEuro parts per thousand 15) had a specificity of 100% to confirm the pathology.