New approaches to molecular diagnostics of prenatal pathology

被引：0
作者：
Pogorelova T.N. [1 ]
Orlov V.I. [1 ]
Gunko V.O. [1 ]
机构：
[1] Rostov Institute of Obstetrics and Pediatrics, Federal Agency for High-Technological Medical Care, Rostov-on-Don
来源：
Bulletin of Experimental Biology and Medicine | 2011年 / 151卷 / 5期
关键词：
amniotic fluid; difference proteins; gestosis; proteomic analysis;
D O I：
10.1007/s10517-011-1384-y
中图分类号：
学科分类号：
摘要：
Analysis of the spectrum of amniotic fluid proteins in physiological and abnormal pregnancy using proteomic analysis allowed detection of a number of difference proteins, that are absent or, alternatively, appear in gestosis. Among absent proteins, there were NADPH-dependent carbonyl reductase, epidermal fatty acid-binding protein, haptoglobin, calgranulins A and B. In contrast to proteomic spectrum of amniotic fluid in physiological pregnancy, 7 new proteins appear during gestosis, 3 of them were identified: C area of immunoglobulin K-chain, breast cancer metastasis suppressor-1, and protein-1 containing AIG2-like domain. Possible effects of revealed differences in proteomic spectrum on development of main disturbances during gestosis are discussed. Difference proteins detected in amniotic fluid may serve as gestosis markers. © 2011 Springer Science+Business Media, Inc.
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页码：567 / 570
页数：3
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