Synthesis and Antibacterial Activity of Calycanthaceous Alkaloid Derivatives

被引：0
|
作者：
Shaojun Zheng
Yongdong Gu
Rui Zhu
Longbo Li
Hongjin Bai
Jiwen Zhang
机构：
[1] Jiangsu University of Science and Technology,School of Environmental and Chemical Engineering
[2] Tarim University,Key Laboratory of Protection & Utilization of Biological Resources in Tarim Basin of Xinjiang Production and Construction Corps/College of Life Sciences
[3] Key Laboratory of Botanical Pesticide R & D in Shaanxi Province,undefined
来源：
Chemistry of Natural Compounds | 2018年 / 54卷
关键词：
calycanthaceous alkaloids; synthesis; antibacterial activity; agrochemicals; tryptophan;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of 45 calycanthaceous alkaloid derivatives with the tetrahydropyrroloindole core structure was synthesized from tryptophan in good yields. The synthesized compounds were evaluated against five strains of bacteria (Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Escherichia coil, Ralstonia solanacearum, and Pseudomonas aeruginosa). The bioassays indicated that among the synthesized compounds, compounds b3 and b4 exhibited a high degree of activity towards Gram positive B. subtilis. Compounds a14 and a18 displayed a high degree of activity towards R. solanacearum. These results will pave the way for further design, structural modification, and development of calycanthaceous alkaloids as antibacterial agents.
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页码：127 / 130
页数：3
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