NANOG-dependent function of TET1 and TET2 in establishment of pluripotency

被引：0

作者：

Yael Costa

Junjun Ding

Thorold W. Theunissen

Francesco Faiola

Timothy A. Hore

Pavel V. Shliaha

Miguel Fidalgo

Arven Saunders

Moyra Lawrence

Sabine Dietmann

Satyabrata Das

Dana N. Levasseur

Zhe Li

Mingjiang Xu

Wolf Reik

José C. R. Silva

Jianlong Wang

机构：

[1] Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute,Department of Developmental and Regenerative Biology

[2] University of Cambridge,Department of Biochemistry

[3] Tennis Court Road,Department of Internal Medicine

[4] Cambridge CB2 1QR,Department of Pediatrics

[5] UK,undefined

[6] Black Family Stem Cell Institute,undefined

[7] Graduate School of Biological Sciences,undefined

[8] Mount Sinai School of Medicine,undefined

[9] University of Cambridge,undefined

[10] Tennis Court Road,undefined

[11] Cambridge CB2 1QR,undefined

[12] UK,undefined

[13] Epigenetics Programme,undefined

[14] The Babraham Institute,undefined

[15] Cambridge CB22 3AT,undefined

[16] UK,undefined

[17] Cambridge Centre for Proteomics,undefined

[18] Cambridge Systems Biology Centre,undefined

[19] University of Cambridge,undefined

[20] Tennis Court Road,undefined

[21] Cambridge CB2 1QR,undefined

[22] UK,undefined

[23] and Program in Molecular and Cellular Biology,undefined

[24] University of Iowa,undefined

[25] Indiana University,undefined

[26] Centre for Trophoblast Research,undefined

[27] University of Cambridge,undefined

[28] Cambridge CB2 3EG,undefined

[29] UK,undefined

来源：

Nature | 2013年 / 495卷

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摘要：

The authors show that the pluripotency factor NANOG interacts with TET1 and TET2 methylcytosine hydroxylases, and that the hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine enhances the efficiency of somatic cell reprogramming in a NANOG-dependent manner.

引用

页码：370 / 374

页数：4

共 38 条

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