Functions and mechanisms of lncRNA MALAT1 in cancer chemotherapy resistance

被引：0
作者：
Junhui Hou
Gong Zhang
Xia Wang
Yuan Wang
Kefeng Wang
机构：
[1] Shengjing Hospital of China Medical University,Department of Urology
[2] Shengjing Hospital of China Medical University,Department of General Surgery
来源：
Biomarker Research | / 11卷
关键词：
Long non-coding RNA; MALAT1; Chemotherapy resistance; Cancer; Treatment;
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摘要：
Chemotherapy is one of the most important treatments for cancer therapy. However, chemotherapy resistance is a big challenge in cancer treatment. Due to chemotherapy resistance, drugs become less effective or no longer effective at all. In recent years, long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been found to be associated with the development of chemotherapy resistance, suggesting that MALAT1 may be an important target to overcome chemotherapy resistance. In this review, we introduced the main mechanisms of chemotherapy resistance associated with MALAT1, which may provide new approaches for cancer treatment.
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[1]  
Ikeda M(2018)Chemotherapy for hepatocellular carcinoma: current status and future perspectives Jpn J Clin Oncol 48 103-114
[2]  
Aigner J(2011)The role of neoadjuvant chemotherapy in the management of primary breast cancer Minerva Ginecol 63 261-274
[3]  
Falzone L(2018)Evolution of cancer pharmacological treatments at the turn of the third millennium Front Pharmacol 9 1300-1792
[4]  
Salomone S(2014)Drug resistance in cancer: an overview Cancers (Basel) 6 1769-2861
[5]  
Libra M(2009)Introduction to cancer chemotherapeutics Chem Rev 109 2859-39
[6]  
Housman G(2011)Chemotherapy: updates and new perspectives Oncologist 16 30-1140
[7]  
Shewach DS(2017)Impact of recurrence of ovarian cancer on quality of life and outlook for the future Int J Gynecol Cancer 27 1134-1565
[8]  
Kuchta RD(2011)Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer JAMA 306 1557-5390
[9]  
Swain SM(2019)Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance Nat Commun 10 5324-669
[10]  
Colombo N(2017)LncRNA NEAT1 contributes to paclitaxel resistance of ovarian cancer cells by regulating ZEB1 expression via miR-194 Onco Targets Ther 10 5377-33
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