A posterior-to-anterior shift of brain functional dynamics in aging

被引：0
作者：
Han Zhang
Annie Lee
Anqi Qiu
机构：
[1] National University of Singapore,Department of Biomedical Engineering
[2] National University of Singapore,Clinical Imaging Research Center
[3] The Agency for Science,Singapore Institute for Clinical Sciences
[4] Technology and Research,undefined
来源：
Brain Structure and Function | 2017年 / 222卷
关键词：
Brain functional dynamics; Functional connectivity; Brain functional network; Scaffolding mechanism; Resting-state functional magnetic resonance imaging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Convergent evidence from task-based functional magnetic resonance imaging (fMRI) studies suggests a posterior-to-anterior shift as an adaptive compensatory scaffolding mechanism for aging. This study aimed to investigate whether brain functional dynamics at rest follow the same scaffolding mechanism for aging using a large Chinese sample aged from 22 to 79 years (n = 277). We defined a probability of brain regions being hubs over a period of time to characterize functional hub dynamic, and defined variability of the functional connectivity to characterize dynamic functional connectivity using resting-state fMRI. Our results revealed that both functional hub dynamics and dynamic functional connectivity posited an age-related posterior-to-anterior shift. Specifically, the posterior brain region showed attenuated dynamics, while the anterior brain regions showed augmented dynamics in aging. Interestingly, our analysis further indicated that the age-related episodic memory decline was associated with the age-related decrease in the brain functional dynamics of the posterior regions. Hence, these findings provided a new dimension to view the scaffolding mechanism for aging based on the brain functional dynamics.
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页码：3665 / 3676
页数：11
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