The role and potential of sialic acid in human nutrition

被引：0
作者：
B Wang
J Brand-Miller
机构：
[1] Human Nutrition Unit,
[2] School of Molecular and Microbial Biosciences,undefined
[3] University of Sydney,undefined
来源：
European Journal of Clinical Nutrition | 2003年 / 57卷
关键词：
sialic acid; ganglioside; sialyl-oligosaccharides; human milk; infant formula; breastfeeding;
D O I：
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中图分类号：
学科分类号：
摘要：
Sialic acids are a family of nine-carbon acidic monosaccharides that occur naturally at the end of sugar chains attached to the surfaces of cells and soluble proteins. In the human body, the highest concentration of sialic acid (as N-acetylneuraminic acid) occurs in the brain where it participates as an integral part of ganglioside structure in synaptogenesis and neural transmission. Human milk also contains a high concentration of sialic acid attached to the terminal end of free oligosaccharides, but its metabolic fate and biological role are currently unknown. An important question is whether the sialic acid in human milk is a conditional nutrient and confers developmental advantages on breast-fed infants compared to those fed infant formula. In this review, we critically discuss the current state of knowledge of the biology and role of sialic acid in human milk and nervous tissue, and the link between sialic acid, breastfeeding and learning behaviour.
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页码：1351 / 1369
页数：18
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