Mammographic screening and mammographic patterns

被引：0
作者：
Nick Day
Ruth Warren
机构：
[1] University of Cambridge,Strangeways Research Laboratory
[2] Rosie Maternity Hospital,undefined
来源：
Breast Cancer Research | / 2卷
关键词：
dedifferentiation; mammography; mammographic density; screening sensitivity;
D O I：
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学科分类号：
摘要：
Mammography is an effective screening modality for the early detection of breast cancer. The reduction in breast cancer mortality is greater for women aged over 50 at screening than for women aged under 50. Mammography can also contribute to an understanding of the biology of breast cancer. Screening trials provide good evidence for the dedifferentiation of a cancer as it develops over time, and the age dependency of this dedifferentiation explains much of the age difference in the effectiveness of screening. Mammographic density is an important predictor of future breast cancer risk, and has potential as an early endpoint in breast cancer prevention trials. Mammographic density is also an important determinant of mammographic screening sensitivity.
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