Preliminary studies on the hypoglycemic effect of Peganum harmala L. seeds ethanol extract on normal and streptozotocin induced diabetic rats

被引：34

作者：

Singh A.B. ^{[1
]}

Chaturvedi J.P. ^{[2
]}

Narender T. ^{[2
]}

Srivastava A.K. ^{[1
,3
]}

机构：

[1] Biochemistry Division, Central Drug Research Institute

[2] Medicinal and Process Chemistry Division, Central Drug Research Institute

[3] Biochemistry Division, Central Drug Research Institute, Lucknow

来源：

Indian Journal of Clinical Biochemistry | 2008年 / 23卷 / 4期

关键词：

Hyperglycemic; Peganum harmala; Streptozotocin induced diabetic rats; Sucrose challenged;

D O I：

10.1007/s12291-008-0086-3

中图分类号：

学科分类号：

摘要：

Peganum harmala L. (Zygophyllaceae) is a traditional medicine used for the treatment of variety of human ailments, including antidepression, hallucination, antileishmaniasis etc. We report for first time the hypoglycemic activity of the ethanolic extract of this plant at two dose levels of 150 and 250mg/kg bw in sucrose challenged normal as well as in rats with streptozotocin induced diabetes. The oral administration of ethanolic extract causes maximum fall of blood glucose level to 22.9% (p<0.05) and 29.4% (p<0.01) respectively with the two doses in normal and 30.3% (p<0.01) and 48.4% (p<0.001) in diabetic rats. The standard drug metformin treated group showed 28.0% (p<0.01) and 45.5% (p<0.001) respectively in normal and diabetic rats. The above results show that the ethanolic extract of P. harmala is as effective as metformin in reducing the blood glucose levels of normoglycemic and streptozotocin-induced diabetic rats.

引用

页码：391 / 393

页数：2

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