Effects of dipyridamole on Plasmodium falciparum-infected erythrocytes

被引：0

作者：

Mayumi Akaki

Yamaji Nakano

Yoshihiro Ito

Eiji Nagayasu

Masamichi Aikawa

机构：

[1] Research Institute of Science and Technology,

[2] Tokai University,undefined

[3] Isehara,undefined

[4] Kanagawa 259-1193,undefined

[5] Japan,undefined

[6] Division of Applied Research of Molecular Biology,undefined

[7] The Foundation of Research Institute for Production Development,undefined

[8] 15 Shimogamo Morimoto-cho,undefined

[9] Sakyo-ku,undefined

[10] Kyoto 606-0805,undefined

[11] Japan,undefined

[12] New address: Graduate School of Agricultural and Life Sciences,undefined

[13] University of Tokyo,undefined

[14] Yayoi Bunkyo-ku,undefined

[15] Tokyo 113-8675,undefined

[16] Japan,undefined

来源：

Parasitology Research | 2002年 / 88卷

关键词：

Effective Treatment; Platelet Aggregation; Inhibitory Concentration; Plasmodium; Plasmodium Falciparum;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This study assessed the antimalarial activity of dipyridamole, a well-known vasodilator and inhibitor of platelet aggregation. Dipyridamole was effective against all of the erythrocytic stages such as rings, trophozoites and schizonts, and induced ultrastructual changes during the transition from trophozoite to schizont in vitro. Merozoites were also inhibited from invading dipyridamole-treated erythrocytes. It seems that dipyridamole binds to the erythrocyte membrane blocking the receptors for the merozoite. The 50% inhibitory concentration (IC50) of dipyridamole against Plasmodium falciparum infection was 30 nM. The IC50 of chloroquine decreased from 97.0 nM to 13.7 nM when combined with dipyridamole (0.1 nM). Therefore, we suggest that dipyridamole has antiplasmodial activity due to its ability to arrest parasite development and by inhibiting merozoite invasion of the erythrocytes. Chloroquine activity against P. falciparum is also enhanced by the addition of dipyridamole. Treatment with a combination of chloroquine and dipyridamole may lead to a more effective treatment for chloroquine-resistant strains of P. falciparum.

引用

页码：1044 / 1050

页数：6