未找到相关数据
Effect of anabolic/androgenic steroids on myosin heavy chain expression in hindlimb muscles of male rats
被引：0
作者：
Philippe Noirez
Arnaud Ferry
机构：
[1] Laboratoire de Physiologie des Adaptations,
[2] Faculté de Médecine Cochin-Port Royal,undefined
[3] Université René Descartes,undefined
[4] 24 Rue du Faubaurg Saint-Jacques,undefined
[5] F-75014,undefined
[6] Paris,undefined
[7] France Fax: +33-1-44412318,undefined
[8] Unité de Formation et de Recherche en Sciences et Techniques des Activités Physiques et Sportives,undefined
[9] Université René Descartes,undefined
[10] Paris,undefined
[11] France,undefined
来源：
European Journal of Applied Physiology
|
2000年
/
81卷
关键词：
Key words Exercise;
Male sex hormones;
Muscle;
Myosin heavy chain;
Nandrolone;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We have examined the effect of male sex hormones on the myosin heavy chain (MHC) expression of the soleus and extensor digitorum longus (EDL) muscles. Young male adult Wistar rats were treated over a 25-day period with either oil (CON, n = 8), nandrolone (nortestosterone decanoate, NAN, n = 8), nandrolone combined with endurance exercise (treadmill running, NAN+EXE, n = 8), or were castrated (CAS, n = 8). The MHC composition of the soleus and EDL muscles was measured by electrophoresis. Castration and treatment with nandrolone had no effect (P > 0.05) on the relative levels of MHC in the soleus and EDL. In contrast, in NAN+EXE rats, the relative level of MHC-1 increased [slow isoform; mean (SD) 97.6 (4.7)% in NAN+EXE rats, versus 86.5 (7.5)% in CON rats] and MHC-2a decreased [fast isoform; 2.4 (4.7)% in NAN+EXE, versus 13.5 (7.5)% in CON rats], only in the soleus (P < 0.05). In conclusion, it appears that endogenous anabolic/androgenic steroids are not essential for the maintenance of the MHC expression of fast- and slow-twitch muscles in the young adult male rat. In addition, nandrolone combined with endurance exercise induced a shift from a fast to a slower MHC phenotype of the slow-twitch muscle.
引用
收藏
页码：155 / 158
页数：3
相关论文