Targeting PI3K/Akt/HSP90 Signaling Sensitizes Gastric Cancer Cells to Deoxycholate-Induced Apoptosis

被引:0
作者
Maria J. Redlak
Thomas A. Miller
机构
[1] Medical College of Virginia Commonwealth University,Department of Surgery
来源
Digestive Diseases and Sciences | 2011年 / 56卷
关键词
Cell signaling; Heat shock proteins; Apoptosis; AGS cell line;
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页码:323 / 329
页数:6
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[1]  
Vivanco I(2002)The phosphatidylinositol 3-kinase-Akt pathway in human cancer Nature Rev Cancer 2 489-501
[2]  
Sawyers CL(2005)Mechanism of disease: PI3K/AKT signaling in gastrointestinal cancers Gastroenterology 43 1133-1139
[3]  
Michl P(2003)Involvement of PI3/Akt pathway in cell cycle progression, apoptosis and neoplastic transformation: a target for cancer chemotherapy Leukemia 17 590-603
[4]  
Downward J(1999)Cellular survival: a play in three Akts Genes Dev 13 2905-2927
[5]  
Chang F(2003)Rapid accumulation of Akt in mitochondria following phosphatidylinosil 3-kinase activation J Neurochem 87 1427-1435
[6]  
Lee JT(1997)Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bβ J Biol Chem 272 30491-30497
[7]  
Navolanic PM(2000)The PI3K-PDK1 connection: more than just a road to PKB Biochem J 346 561-576
[8]  
Steelman LS(2007)PTEN: its deregulation and tumorigenesis Biol Pharm Bull 30 1624-1627
[9]  
Shelton JG(2004)Hsp70 and Hsp90—a relay team for protein folding Rev Physiol Biochem Pharmacol 151 1-44
[10]  
WLl Blalock(2002)HSP90 inhibitor as novel cancer chemotherapeutic agent Trends Mol Med 8 S55-S61