Collagen type 1 (COL1A1) Sp1 binding site polymorphism is associated with osteoporotic fractures but not with bone density in post-menopausal women from the Canary Islands: a preliminary study

被引:0
作者
Mary C. Navarro
Manuel Sosa
Javier del Pino-Montes
Armando Torres
Eduardo Salido
Pedro Saavedra
Luis Corral-Gudino
Carlos A. Montilla
机构
[1] University of Las Palmas de Gran Canaria,Osteoporosis Research Group, Bone Metabolic Unit, Hospital University Insular
[2] University of Salamanca,Department of Medicine
[3] University of La Laguna,Investigation Unit
[4] University of Las Palmas de Gran Canaria,Bone Metabolic Unit
[5] Faculty of Medicine,undefined
来源
Aging Clinical and Experimental Research | 2007年 / 19卷
关键词
Bone density; Canary Islands; collagen; fracture; genotype; osteoporosis;
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摘要
Background and aims: An association between the polymorphism for transcription factor Sp1 in the gene COL1A1 and low bone density (BMD) and osteoporotic fractures has been described but not confirmed for all races and ages. The aim of this preliminary work was to ascertain whether this association is present in women from the Canary Islands. Methods: Polymerase chain reaction RFLP was used to determine COL1A1 polymorphism Sp1 in 199 consecutive outpatient post-menopausal Caucasian women from the Canary Islands, aged 50–70 years. BMD was measured at lumbar spine and hip by DXA and at third lumbar vertebrae by QCT. Prevalent vertebral fractures were recorded on standard lateral X-ray film. Non-vertebral osteoporotic fractures were registered by medical record and self-reported history. Biochemical markers (serum osteocalcin, tartrate-resis-tant acid phosphatase), blood calcium and phosphate were also assessed. Results: Distribution genotypes were 113 (50.8%) GG homozygotes, 73 (36.7%) Ss heterozygotes and 7 (3.5%) TT homozygotes. All patients with osteoporotic fractures carried the GG allele more frequently than TT homozygotic women. The odds ratio was 3.01 (95% CI 1.6–5.7) for prevalent vertebral fractures (n=62) and 2.33 (95% CI 1.2–4.4) for all osteoporotic fractures (n=65) for the T-carrying allele vs TT homozygotic women. There was no difference in BMD measured by DXA or QCT, nor in bone markers, blood calcium or phosphate. Conclusions: This preliminary study confirmed that the presence of at least one copy of the T allele is associated with osteoporotic fractures, but not with low BMD, in women from the Canary Islands.
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页码:4 / 9
页数:5
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