Expression of cyclooxygenase-2 and epidermal growth factor receptor in primary and recurrent glioblastoma multiforme

被引:0
作者
Peter Sminia
T. Rianne Stoter
Paul van der Valk
Paula H.M. Elkhuizen
Thea M. Tadema
Gitta K. Kuipers
W. Peter Vandertop
M. Vincent M. Lafleur
Ben J. Slotman
机构
[1] VU University Medical Center,Department of Radiation Oncology
[2] VU University Medical Center,Department of Neuropathology
[3] VU University Medical Center,Department of Neurosurgery
来源
Journal of Cancer Research and Clinical Oncology | 2005年 / 131卷
关键词
COX-2; EGFR; Primary and recurrent glioblastoma multiforme; Immunohistochemistry;
D O I
暂无
中图分类号
学科分类号
摘要
Purpose: To investigate the pattern and level of cyclooxygenase-2 (COX-2) expression in a series of high grade primary and recurrent glioblastoma multiforme (GBM) and correlation with time to recurrence and patients’ survival following therapy. The relationship between COX-2 and epidermal growth factor receptor (EGFR) immunoreactivities was evaluated. Materials and methods: Specimens of 14 primary and 14 recurrent GBMs (eight pairs) following surgery and full course radiation therapy were processed for immunostaining on COX-2 and EGFR. Tumor cell positivity was semi-quantitatively scored. COX-2 scores of the primary tumor and recurrence were correlated with the time to radiological tumor progression and patients’ survival. Results: COX-2 positive tumor cells were disseminated throughout the tumor parenchyma. The intensity and pattern of COX-2 expression were heterogeneous, with predominant expression in areas surrounding tumor necrosis. Scoring of COX-2 positivity revealed values between 1 and 80% of the cells. Primary GBMs with COX-2 expression levels between 25% and 70% of the tumor cells showed a shorter time to radiological recurrence than GBMs with <10% COX-2 positive tumor cells (respectively, 219±50 and 382±77 days). No correlation was found between the COX-2 expression in the primary tumor and patients’ survival (rs=−0.073) following therapy. No correlation was found either between COX-2 and EGFR immunoreactivity. Conclusions: Immunohistochemical expression of COX-2 in GBM showed large variation. Hence, determination of COX-2 expression in tumor specimen for each individual might be relevant for selection of those patients, who could benefit from adjuvant therapy with selective COX-2 inhibitors.
引用
收藏
页码:653 / 661
页数:8
相关论文
共 50 条
[41]   Relationship between cyclooxygenase-2 and human epidermal growth factor receptor 2 in vascular endothelial growth factor C up-regulation and lymphangiogenesis in human breast cancer [J].
Bhattacharjee, Rabindra N. ;
Timoshenko, Alexander V. ;
Cai, Jing ;
Lala, Peeyush K. .
CANCER SCIENCE, 2010, 101 (09) :2026-2032
[42]   Human epidermal growth factor receptor-2 expression in primary and metastatic gastric cancer [J].
Yiting Geng ;
Xiaofeng Chen ;
Jinrong Qiu ;
Yue Zhou ;
Jian Wang ;
Lingxiang Liu ;
Yongfeng Shao ;
Yongmei Yin .
International Journal of Clinical Oncology, 2014, 19 :303-311
[43]   Human epidermal growth factor receptor-2 expression in primary and metastatic gastric cancer [J].
Geng, Yiting ;
Chen, Xiaofeng ;
Qiu, Jinrong ;
Zhou, Yue ;
Wang, Jian ;
Liu, Lingxiang ;
Shao, Yongfeng ;
Yin, Yongmei .
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2014, 19 (02) :303-311
[44]   Significance of human epidermal growth factor receptor 2 expression in colorectal cancer [J].
Tu, Jinhua ;
Yu, Yinghao ;
Liu, Wei ;
Chen, Shunping .
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2015, 9 (01) :17-24
[45]   Expression of cyclooxygenase-2 in colonic polyps [J].
Wasilewicz, Michal P. ;
Kolodziej, Blanka ;
Bojulko, Teresa ;
Kaczmarczyk, Mariusz ;
Sulzyc-Bielicka, Violetta ;
Bielicki, Dariusz .
POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ-POLISH ARCHIVES OF INTERNAL MEDICINE, 2010, 120 (09) :313-320
[46]   Cyclooxygenase-2 expression in cervical cancer [J].
Mandic, Aljosa ;
Usaj-Knezevic, Slavica ;
Kapicl, Tatjana Ivkovic ;
Nincic, Dejan ;
Malenkovic, Goran .
VOJNOSANITETSKI PREGLED, 2014, 71 (11) :997-1005
[47]   Cyclooxygenase-2 Expression in Animal Cancers [J].
Dore, M. .
VETERINARY PATHOLOGY, 2011, 48 (01) :254-265
[48]   Expression of Human Epidermal Growth Factor Receptor 2 in Meningiomas [J].
Ramezani, Mazaher ;
Firoozabadi, Hanieh ;
Rezaei, Mansour ;
Khazaei, Sedigheh ;
Sadeghi, Masoud .
INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY, 2020, 41 (01) :15-18
[49]   Expression of cyclooxygenase-2 in endometrial adenocarcinoma [J].
Kilic, G ;
Gurates, B ;
Garon, J ;
Kang, H ;
Arun, B ;
Lampley, CE ;
Kurzel, R ;
Ashfaq, R .
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2005, 26 (03) :271-274
[50]   Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways:: Evidence for involvement of transactivation of the epidermal growth factor receptor [J].
Spinella, F ;
Rosanò, L ;
Elia, G ;
Di Castro, V ;
Natali, PG ;
Bagnato, A .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2004, 44 :S140-S143