Enhanced penetration strategies for transdermal delivery

被引:0
作者
Qiaofei Pan
Yinglin Yu
Dong Chen
Genlong Jiao
Xiaowen Liu
机构
[1] Jinan University,Pharmacology, Department of Basic Medical Sciences, Faculty of Medical Science
[2] State Key Laboratory of Oncology in South China,Sun Yat
[3] First Affiliated Hospital of Jinan University,sen University Cancer Center
来源
Frontiers of Chemical Science and Engineering | 2020年 / 14卷
关键词
transdermal delivery; stratum corneum; enhanced penetration; therapeutics;
D O I
暂无
中图分类号
学科分类号
摘要
Transdermal delivery offers several advantages in drug distribution, including convenience, painless administration, avoidance of first-pass metabolism, and ease of termination. However, the natural protective barriers of the skin, such as the stratum corneum, the topmost layer of skin, limit the systemic absorption of external therapeutics via transdermal delivery. Therefore, extensive application of transdermal delivery in medical treatment has been limited. Over the past few years, many formulation strategies and physical technologies, therefore, have been developed to enhance transdermal delivery. This review summarizes various formulation strategies proposed for transdermal delivery and their application in medical treatment.
引用
收藏
页码:378 / 388
页数:10
相关论文
共 483 条
  • [1] Jin J F(2015)The optimal choice of medication administration route regarding intravenous, intramuscular, and subcutaneous injection Patient Preference and Adherence 9 923-942
  • [2] Zhu L L(1972)Influence of route of administration on drug availability Journal of Pharmaceutical Sciences 61 70-74
  • [3] Xu H M(1988)Pharmaceutical and medical aspects of bioadhesive systems for drug administration Drug Development and Industrial Pharmacy 14 283-318
  • [4] Wang H F(2008)Transdermal drug delivery Nature Biotechnology 26 1261-1268
  • [5] Feng X Q(2004)Current status and future potential of transdermal drug delivery Nature Reviews. Drug Discovery 3 115-124
  • [6] Zhu X P(2011)Transdermal delivery of proteins AAPS PharmSciTech 12 431-441
  • [7] Zhou Q(2019)Biocompatible nanoparticles and vesicular systems in transdermal drug delivery for various skin diseases International Journal of Pharmaceutics 555 49-62
  • [8] Rowland M(2015)Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum Pharmaceutics 7 438-470
  • [9] Duchene D(2006)Transdermal protein delivery by a coadministered peptide identified via phage display Nature Biotechnology 24 455-460
  • [10] Touchard F(2015)Chemical penetration enhancers Therapeutic Delivery 6 1053-1061