Dedifferentiated parosteal osteosarcoma of the maxilla: A case report and review of the literature

被引：6

作者：

Miyashita H. ^{[1
]}

Yoshida K. ^{[2
]}

Soma T. ^{[1
]}

Kameyama K. ^{[3
]}

Sasaki A. ^{[3
]}

Hisaoka M. ^{[4
]}

Yazawa M. ^{[5
]}

Morioka H. ^{[6
]}

Takahashi M. ^{[1
]}

Nakagawa T. ^{[1
]}

Kawana H. ^{[1
]}

机构：

[1] Department of Dentistry and Oral Surgery, Division of Oral and Maxillofacial Surgery, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo

[2] Department of Neurosurgery, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo

[3] Department of Diagnostic Pathology, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo

[4] Department of Pathology and Oncology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu

[5] Department of Plastic and Reconstructive Surgery, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo

[6] Department of Orthopaedic Surgery, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo

来源：

Journal of Medical Case Reports | / 12卷 / 1期

关键词：

Case report; Chemotherapy; Dedifferentiated; Head and neck; Maxilla; Parosteal osteosarcoma;

D O I：

10.1186/s13256-018-1747-3

中图分类号：

学科分类号：

摘要：

Background: Parosteal osteosarcomas are usually low-grade tumors, however, sometimes they transform to high-grade tumors, which is named dedifferentiation. This phenomenon has been reported in long bones. Recently, we encountered a patient with dedifferentiated parosteal osteosarcoma occurring in the maxilla. Here, we report a first case of dedifferentiated parosteal osteosarcoma of the head and neck region. Case presentation: A 45-year-old Japanese woman with a refractory bone lesion in the maxilla presented to our hospital. A biopsy showed atypical spindle cell proliferation involving dedifferentiated high-grade component, which was diagnosed as dedifferentiated parosteal osteosarcoma. Three cycles of neoadjuvant chemotherapy using ifosfamide and pirarubicin were performed followed by sub-total maxillectomy. Histopathological results showed that neoadjuvant chemotherapy was effective for high-grade component. The decision to perform adjuvant chemotherapy (cisplatin and pirarubicin) was made because distant metastasis has been reported, even in cases with dedifferentiated parosteal osteosarcoma in which complete necrosis of high-grade component was achieved due to neoadjuvant chemotherapy. There was no recurrence 15 months after surgery. Conclusions: Dedifferentiated parosteal osteosarcoma can occur in the head and neck region. Chemotherapy including anthracycline anticancer agent could be effective for high-grade component of dedifferentiated parosteal osteosarcoma. © 2018 The Author(s).

引用

共 13 条

[1]

Wold L.E., Unni K.K., Beabout J.W., Sim F.H., Dahlin D.C., Dedifferentiated parosteal osteosarcoma, J Bone Joint Surg Am, 66, pp. 53-59, (1984)

[2]

Okada K., Frassica F.J., Sim F.H., Beabout J.W., Bond J.R., Unni K.K., Parosteal osteosarcoma. A clinicopathological study, J Bone Joint Surg Am, 76, pp. 366-378, (1994)

[3]

Bertoni F., Bacchini P., Staals E.L., Davidovitz P., Dedifferentiated parosteal osteosarcoma: The experience of the Rizzoli Institute, Cancer, 103, pp. 2373-2382, (2005)

[4]

Sheth D.S., Yasko A.W., Raymond A.K., Ayala A.G., Carrasco C.H., Benjamin R.S., Et al., Conventional and dedifferentiated parosteal osteosarcoma. Diagnosis, treatment, and outcome, Cancer, 78, pp. 2136-2145, (1996)

[5]

Yoshida A., Ushiku T., Motoi T., Beppu Y., Fukayama M., Tsuda H., Et al., MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma: Correlation with a dedifferentiated subtype, Am J Surg Pathol, 36, pp. 423-431, (2012)

[6]

Enneking W.F., Spanier S.S., Goodman M.A., A system for the surgical staging of musculoskeletal sarcoma, Clin Orthop Relat Res, 153, pp. 106-120, (1980)

[7]

Tanaka K., Mizusawa J., Fukuda H., Araki N., Chuman H., Takahashi M., Et al., Perioperative chemotherapy with ifosfamide and doxorubicin for high-grade soft tissue sarcomas in the extremities (JCOG0304), Jpn J Clin Oncol, 45, pp. 555-561, (2015)

[8]

Miyashita H., Asoda S., Horie N., Usuda S., Kato S., Muraoka W., Et al., A titanium screw-retaining temporary denture on the raw surface muscular flap for the immediate maxillary reconstruction, J Oral Maxillofac Surg Med Pathol, 28, pp. 8-12, (2016)

[9]

Rosen G., Caparros B., Huvos A.G., Kosloff C., Nirenberg A., Cacavio A., Et al., Preoperative chemotherapy for osteogenic sarcoma: Selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy, Cancer, 49, pp. 1221-1230, (1982)

[10]

Naito M., Suzukamo Y., Nakayama T., Hamajima N., Fukuhara S., Linguistic adaptation and validation of the General Oral Health Assessment Index (GOHAI) in an elderly Japanese population, J Public Health Dent, 66, pp. 273-275, (2006)

← 1 2 →