Surface-Enhanced Raman Spectroscopy Study of 4-ATP on Gold Nanoparticles for Basal Cell Carcinoma Fingerprint Detection

被引：0

作者：

Luu Manh Quynh

Nguyen Hoang Nam

K. Kong

Nguyen Thi Nhung

I. Notingher

M. Henini

Nguyen Hoang Luong

机构：

[1] Vietnam National University,Faculty of Physics, Hanoi University of Science

[2] Hanoi,Nano and Energy Center, Hanoi University of Science

[3] Vietnam National University,School of Physics and Astronomy

[4] Hanoi,undefined

[5] Nottingham University,undefined

来源：

Journal of Electronic Materials | 2016年 / 45卷

关键词：

Skin cancer; basal cell carcinoma; surface-enhanced Raman scattering; gold nanoparticles;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The surface-enhanced Raman signals of 4-aminothiophenol (4-ATP) attached to the surface of colloidal gold nanoparticles with size distribution of 2 to 5 nm were used as a labeling agent to detect basal cell carcinoma (BCC) of the skin. The enhanced Raman band at 1075 cm−1 corresponding to the C-S stretching vibration in 4-ATP was observed during attachment to the surface of the gold nanoparticles. The frequency and intensity of this band did not change when the colloids were conjugated with BerEP4 antibody, which specifically binds to BCC. We show the feasibility of imaging BCC by surface-enhanced Raman spectroscopy, scanning the 1075 cm−1 band to detect the distribution of 4-ATP-coated gold nanoparticles attached to skin tissue ex vivo.

引用

页码：2563 / 2568

页数：5

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