An Overview of Novel Therapies for Acute Hereditary Angioedema

被引：0
作者：
Rafael Firszt
Michael M. Frank
机构：
[1] Duke University Medical Center,Department of Pediatrics
来源：
American Journal of Clinical Dermatology | 2010年 / 11卷
关键词：
Angioedema; Tranexamic Acid; Fresh Freeze Plasma; Hereditary Angioedema; Icatibant;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Hereditary angioedema is an episodic swelling disorder with autosomal dominant inheritance. Attacks are characterized by nonpitting edema of external or mucosal body surfaces. Patients often present with swelling of the extremities, abdominal pain, and swelling of the mouth and throat, which can at times lead to asphyxiation. The disease is caused by a mutation in the gene encoding the complement C1-inhibitor protein, which leads to unregulated production of bradykinin.
引用
收藏
页码：383 / 388
页数：5
相关论文
共 89 条
[21]  
Zuraw B.L.(1982)Ambiguous genitalia in a term infant due to exposure to danazol in utero [letter] Am J Dis Child 136 474-22
[22]  
Markovic S.N.(1972)Epsilon aminocaproic acid therapy of hereditary angioneurotic edema: a double-blind study N Engl J Med 286 808-8
[23]  
Inwards D.J.(2010)Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema N Engl J Med 363 513-6
[24]  
Phyliky R.P.(2009)Efficacy of human C1 esterase inhibitor concentrate compared with placebo in acute hereditary angioedema attacks J Allergy Clin Immunol 124 801-4
[25]  
Cacoub P.(1980)Replacement therapy in hereditary angioedema: successful treatment of acute episodes of angioedema with partly purified C1 inhibitor N Engl J Med 302 542-9
[26]  
Fremeaux-Bacchi V.(1996)Treatment of hereditary angioedema with a vapor-heated C1 inhibitor concentrate N Engl J Med 334 1630-8
[27]  
De Lacroix I.(1979)Hereditares angioneurtisches: Odem.Klinik sowie erweiterte diagnostiche und therapeutische Moglinkeiten Dtsch Med Wochenschr 11 405-7
[28]  
Caldwell J.R.(2001)Treatment of 193 episodes of laryngeal edemaWith C1 inhibitor concentrate in patients with hereditary angioedema Arch Intern Med 161 714-37
[29]  
Ruddy S.(2003)How do we treat patients with hereditary angioedema Transfus Apher Sci 29 221-8
[30]  
Schur P.H.(2004)Canadian 2003 International Consensus algorithm for the diagnosis, therapy, and management of hereditary angioedema J Allergy Clin Immunol 114 629-7
123456789