Therapeutic Approaches for Zika Virus Infection of the Nervous System

被引:0
作者
Rachel P. M. Abrams
Jamie Solis
Avindra Nath
机构
[1] National Institutes of Health,Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke
来源
Neurotherapeutics | 2017年 / 14卷
关键词
Zika virus; Drug discovery; Antiviral agents; Microcephaly; Congenital Zika syndrome; Guillain; Barré syndrome;
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中图分类号
学科分类号
摘要
Zika virus has spread rapidly in the Americas and has caused devastation of human populations affected in these regions. The virus causes teratogenic effects involving the nervous system, and in adults and children can cause a neuropathy similar to Guillain-Barré syndrome, an anterior myelitis, or, rarely, an encephalitis. While major efforts have been undertaken to control mosquito populations that spread the virus and to develop a vaccine, drug development that directly targets the virus in an infected individual to prevent or treat the neurological manifestations is necessary. Rational and targeted drug development is possible since the viral life cycle and the structure of the key viral proteins are now well understood. While several groups have identified therapeutic candidates, their approaches differ in the types of screening processes and viral assays used. Animal studies are available for only a few compounds. Here we provide an exhaustive review and compare each of the classes of drugs discovered, the methods used for drug discovery, and their potential use in humans for the prevention or treatment of neurological complications of Zika virus infection.
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页码:1027 / 1048
页数:21
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