Expression of MATE1, P-gp, OCTN1 and OCTN2, in epithelial and immune cells in the lung of COPD and healthy individuals

[1] Backman P(2014)Advances in inhaled technologies: understanding the therapeutic challenge, predicting clinical performance, and designing the optimal inhaled product Clin Pharmacol Ther 95 509-520

[2] Adelmann H(2011)Challenges in inhaled product development and opportunities for open innovation Adv Drug Deliv Rev 63 69-87

[3] Petersson G(2010)Membrane transporters in drug development Nat Rev Drug Discov 9 215-236

[4] Jones CB(2010)Drug transporters in the lung--do they play a role in the biopharmaceutics of inhaled drugs? J Pharm Sci 99 2240-2255

[5] Forbes B(2011)Spatial expression and functionality of drug transporters in the intact lung: objectives for further research Adv Drug Deliv Rev 63 110-118

[6] Asgharian B(2014)Gene expression analysis of membrane transporters and drug-metabolizing enzymes in the lung of healthy and COPD subjects Pharmacol Res Perspect 2 e00054-1027

[7] Dailey LA(2011)Xenobiotic metabolism and disposition in human lung: transcript profiling in non-tumoral and tumoral tissues Biochimie 93 1012-3406

[8] Ferguson D(2013)Quantitative expression of human drug transporter proteins in lung tissues: analysis of regional, gender, and interindividual differences by liquid chromatography-tandem mass spectrometry J Pharm Sci 102 3395-7242

[9] Gerde P(2013)Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2 J Med Chem 56 7232-60

[10] Gumbleton M(2007)Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway Am J Respir Cell Mol Biol 36 53-195

[1] Backman P(2014)Advances in inhaled technologies: understanding the therapeutic challenge, predicting clinical performance, and designing the optimal inhaled product Clin Pharmacol Ther 95 509-520

[2] Adelmann H(2011)Challenges in inhaled product development and opportunities for open innovation Adv Drug Deliv Rev 63 69-87

[3] Petersson G(2010)Membrane transporters in drug development Nat Rev Drug Discov 9 215-236

[4] Jones CB(2010)Drug transporters in the lung--do they play a role in the biopharmaceutics of inhaled drugs? J Pharm Sci 99 2240-2255

[5] Forbes B(2011)Spatial expression and functionality of drug transporters in the intact lung: objectives for further research Adv Drug Deliv Rev 63 110-118

[6] Asgharian B(2014)Gene expression analysis of membrane transporters and drug-metabolizing enzymes in the lung of healthy and COPD subjects Pharmacol Res Perspect 2 e00054-1027

[7] Dailey LA(2011)Xenobiotic metabolism and disposition in human lung: transcript profiling in non-tumoral and tumoral tissues Biochimie 93 1012-3406

[8] Ferguson D(2013)Quantitative expression of human drug transporter proteins in lung tissues: analysis of regional, gender, and interindividual differences by liquid chromatography-tandem mass spectrometry J Pharm Sci 102 3395-7242

[9] Gerde P(2013)Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2 J Med Chem 56 7232-60

[10] Gumbleton M(2007)Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway Am J Respir Cell Mol Biol 36 53-195