Investigation of heat and mass transfer behavior of mannitol during vial freeze-drying

被引：0
作者：
M. Muneeshwaran
G. Srinivasan
B. Raja
Chi-Chuan Wang
机构：
[1] National Chiao Tung University,Department of Mechanical Engineering
[2] Indian Institute of Technology,Department of Mechanical Engineering
[3] Indian Institute of Information Technology,Department of Mechanical Engineering
[4] Design,undefined
[5] and Manufacturing,undefined
来源：
Journal of Thermal Analysis and Calorimetry | 2022年 / 147卷
关键词：
Vial configuration; Freeze-drying; Sublimation; Mannitol; Heat transfer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The vial design feature, such as the base curvature, acts as the primary heat transfer barrier in the lyophilization process. In this study, heat and mass transport characteristics of mannitol (5%) during vial freeze-drying are numerically investigated by including the vial base curvature effects. The influence of the product fill height, chamber pressure, and the vial base curvature on the product temperature, drying time, and mass transfer resistance is analyzed in detail. The diameter of the vial is taken as 15 mm, while the fill height of the product is varied from 3 to 5 mm. The chamber pressure is maintained between 5 and 50 Pa. The results revealed that the product with a 3 mm fill height experienced a 2.5 °C lower temperature than the product with a 5 mm fill height. As opposed to the flat vial predictions, if the vial base curvature effects are considered, the drying time is increased by 1.96 and 3.8 h for the 3 mm and 5 mm fill heights, respectively. The increased drying time is attributed to the reduced direct contact area between the vial and shelf and the vapor entrainment in the gap. The results showed that the dry layer mass transfer resistance contributes to 95% of the total mass transfer resistance; however, the contribution of semi-stoppered vial resistance is 1–2% only.
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页码：2393 / 2404
页数：11
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共 93 条
[1]  
Yamamoto Y(2020)Freeze-concentrated glass-like transition temperature of carbohydrate–phosphate buffered saline systems and impact on collapse of freeze-dried solids J Therm Anal Calorim. 142 1-9
[2]  
Hagura Y(2019)A study of the drying behaviour of various types of hydrated hydroxypropyl cellulose (HPC) and their mixtures with drugs of different solubility using DSC J Therm Anal Calorim. 143 1-8
[3]  
Kawai K(2009)Impact of freezing process on salt diffusivity of seafood: application to salmon (Salmo salar) using conventional and pressure shift freezing Food Bioprocess Technol 2 257-262
[4]  
Talik P(2020)Evaluation of immersion-contact type heat transfer for continuous pharmaceutical spin freeze-drying process J Food Process Eng. 43 e13153-25
[5]  
Hubicka U(1995)Progress in food dehydration Trends Food Sci Technol 6 20-1237
[6]  
Alizadeh E(1984)Mass and heat-transfer in vial freeze-drying of pharmaceuticals—role of the vial J Pharm Sci-Us 73 1224-263
[7]  
Chapleau N(2019)Exploring the chemical space for freeze-drying excipients Int J Pharm 566 254-475
[8]  
de-Lamballerie M(2020)Considerations on protein stability during freezing and its impact on the freeze-drying cycle: a design space approach J Pharm Sci 109 464-129
[9]  
Le-Bail A(2019)On the use of a micro freeze-dryer for the investigation of the primary drying stage of a freeze-drying process Eur J Pharm Biopharm 141 121-796
[10]  
Srinivasan G(2020)Use of a temperature ramp approach (TRA) to design an optimum and robust freeze-drying process for pharmaceutical formulations Int J Pharm 578 119116-728
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