Genetic testing in children

被引:0
作者
Shubha Phadke
Mamatha Gowda
机构
[1] Sanjay Gandhi Postgraduate Institute of Medical Sciences,the Department of Medical Genetics
[2] Sanjay Gandhi Postgraduate Institute of Medical Sciences,Head of the Department of Medical Genetics
来源
Indian Pediatrics | 2013年 / 50卷
关键词
Child; Genetic testing; Guidance Ethics; Utility;
D O I
暂无
中图分类号
学科分类号
摘要
Increasing availability of DNA based tests in clinical practice has lead to widespread debate on the ethical issues involved. The wider usage of these tests in children has raised many questions regarding the ethics, validity of the request and its effects on child’s psychosocial well-being. Though there have been much discussion with many studies attempting to address the issue, there is no consensus. Formulation of guidelines has been hampered by the diversity of tests available for varied indications and lack of research studying the effects of testing in children over a time. Some tests have valid indications with proven benefits over harms while others have less clear justification. We attempt to address this issue with the intent to sensitize the caregivers regarding various aspects to be considered before offering any genetic tests in children.
引用
收藏
页码:823 / 827
页数:4
相关论文
共 21 条
[1]  
Wade CH(1995)Points to consider: Ethical, Legal and Psychosocial implications of genetic testing in children and adolescents Am J Hum Genet. 57 1233-1241
[2]  
Wilfond BS(2010)Effects of genetic risk information on children’s psychosocial wellbeing: A systematic review of the literature Genet Med 12 317-326
[3]  
McBride CM(2011)Current concepts in disorders of sexual development J Clin Res Pediatr Endocrinol. 3 105-114
[4]  
Öçal G(2002)Genetic testing N Engl J Med. 347 23-764
[5]  
Burke W(2011)Multiple endocrine neoplasia type 2: An overview Genet Med. 13 755-545
[6]  
Moline J(1998)Members of the Breast Cancer Working Group of the Stanford Program in Genomics, Ethics, and Society. Genetic Testing for BRCA1 and BRCA2: Recommendations of the Stanford Program in Genomics, Ethics, and Society J Women Hlth 7 531-94
[7]  
Eng C(1991)Testing for germline p53 mutations in cancer families Cancer Epid Biomarkers Prev 1 91-13
[8]  
Koenig BA(2012)Ethical issues in newborn screening in the genomic era Ann Rev Genomics Hum Genet. 13 1-S210
[9]  
Greely HT(2010)Expanded newborn screening: reducing harm, assessing benefit J Inherit Metab Dis. 30 S205-880
[10]  
McConnell LM(2011)Ethical considerations associated with clinical use of next-generation sequencing in children Pediatr. 159 879-622