Tesaglitazar, a novel dual peroxisome proliferator-activated receptor α/γ agonist, dose-dependently improves the metabolic abnormalities associated with insulin resistance in a non-diabetic population

Reaven GM(1988)Banting lecture 1988. Role of insulin resistance in human disease Diabetes 37 1595-1607

Reaven GM(1995)Pathophysiology of insulin resistance in human disease Physiol Rev 75 473-486

Haffner SM(1995)A preponderance of small dense LDL is associated with specific insulin, proinsulin and the components of the insulin resistance syndrome in non-diabetic subjects Diabetologia 38 1328-1336

Mykkanen L(2002)Components of the ‘metabolic syndrome’ and incidence of type 2 diabetes Diabetes 51 3120-3127

Robbins D(2003)The metabolic syndrome as predictor of type 2 diabetes: the San Antonio Heart Study Diabetes Care 26 3153-3159

Hanson RL(1990)Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA 263 2893-2898

Imperatore G(2001)Cardiovascular morbidity and mortality associated with the metabolic syndrome Diabetes Care 24 683-689

Bennett PH(1999)Clustering of metabolic factors and coronary heart disease Arch Intern Med 159 1104-1109

Knowler WC(2003)Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study Circulation 108 414-419

Lorenzo C(2002)The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men JAMA 288 2709-2716

Reaven GM(1988)Banting lecture 1988. Role of insulin resistance in human disease Diabetes 37 1595-1607

Reaven GM(1995)Pathophysiology of insulin resistance in human disease Physiol Rev 75 473-486

Haffner SM(1995)A preponderance of small dense LDL is associated with specific insulin, proinsulin and the components of the insulin resistance syndrome in non-diabetic subjects Diabetologia 38 1328-1336

Mykkanen L(2002)Components of the ‘metabolic syndrome’ and incidence of type 2 diabetes Diabetes 51 3120-3127

Robbins D(2003)The metabolic syndrome as predictor of type 2 diabetes: the San Antonio Heart Study Diabetes Care 26 3153-3159

Hanson RL(1990)Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA 263 2893-2898

Imperatore G(2001)Cardiovascular morbidity and mortality associated with the metabolic syndrome Diabetes Care 24 683-689

Bennett PH(1999)Clustering of metabolic factors and coronary heart disease Arch Intern Med 159 1104-1109

Knowler WC(2003)Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study Circulation 108 414-419

Lorenzo C(2002)The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men JAMA 288 2709-2716