IL-6 promoter polymorphisms in rheumatoid arthritis

被引：0
|
作者：
M Pascual
A Nieto
L Matarán
A Balsa
D Pascual-Salcedo
J Martín
机构：
[1] Instituto de Parasitología y Biomedicina “López Neyra”,
[2] CSIC,undefined
[3] Servicio de Reumatología,undefined
[4] Hospital Virgen de las Nieves,undefined
[5] Hospital Universitario La Paz,undefined
[6] Universidad Autónoma,undefined
来源：
Genes & Immunity | 2000年 / 1卷
关键词：
IL-6; polymorphism; rheumatoid arthritis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We investigated the possible association between the IL-6 promoter polymorphisms, at positions −622 and −174, and susceptiblity to, and/or outcome of, rheumatoid arthritis (RA). A total of 163 patients with RA and 157 healthy controls were genotyped for IL-6 using a PCR-RFLP method. The −622 and −174 alleles were in complete linkage disequilibrium. No difference was observed in the distribution of IL-6 promoter genotype or allele frequencies between RA patients and controls. However, a significant difference in the mean age at disease onset between IL-6 genotypes was observed. The present data appear to rule out an important role of IL-6 promoter polymorphisms in the susceptibility to RA. However, IL-6 genotypes may contribute to the pathogenesis of the disease by influencing the age at disease onset.
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页码：338 / 340
页数：2
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