Hepatic arterial infusion combined with systemic chemotherapy induced complete response of metachronous liver metastases after resection of pancreatic insulinoma

被引：2

作者：

Kiyozumi Y. ^{[1
]}

Takamori H. ^{[1
]}

Nakahara O. ^{[1
]}

Ikuta Y. ^{[1
]}

Chikamoto A. ^{[1
]}

Beppu T. ^{[1
]}

Baba H. ^{[1
]}

机构：

[1] Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556

来源：

Clinical Journal of Gastroenterology | 2013年 / 6卷 / 6期

关键词：

Chemotherapy; Hepatic arterial infusion; Pancreatic insulinoma;

D O I：

10.1007/s12328-013-0437-3

中图分类号：

学科分类号：

摘要：

Insulinomas are the most common functioning pancreatic neuroendocrine tumors (PNETs). We herein present the case of a 5-year survivor with insulinoma after complete response of postoperative liver metastases to hepatic arterial infusion combined with systemic chemotherapy. A 58-year-old woman was admitted to our hospital following loss of consciousness. Examination revealed a pancreatic tumor, and she underwent distal pancreatectomy following diagnosis of insulinoma. Superparamagnetic iron oxide magnetic resonance imaging (SPIO-MRI) revealed multiple liver metastases 3 months after surgery. Therefore, we performed hepatic arterial infusion of 5-fluorouracil (5-FU) combined with systemic gemcitabine infusion. We observed complete ablation of all metastatic liver nodules after 11 cycles of the chemotherapy using MRI. We continued this chemotherapy regimen for 20 cycles, and the patient remains alive without any recurrence 7 years after surgery. © Springer 2013.

引用

页码：496 / 499

页数：3

共 8 条

[1] Vaidakis D., Karoubalis J., Pappa T., Piaditis G., Zografos G.N., Pancreatic insulinoma: Current issues and trends, Hepatobiliary Pancreat Dis Int, 9, pp. 234-241, (2010)
[2] Danforth Jr. D.N., Gorden P., Brennan M.F., Metastatic insulin-secreting carcinoma of the pancreas: Clinical course and the role of surgery, Surgery, 96, pp. 1027-1037, (1984)
[3] Klistra D.S., Arnold R., Capella C., Hruban R.H., Kloppel G., Komminoth P., Et al., Neuroendocrine neoplasms of the pancreas, WHO Classification of Tumours of the Digestive System, pp. 322-326, (2010)
[4] De Herder W.W., Niederle B., Scoazec J.-Y., Pauwels S., Kloppel G., Falconi M., Kwekkeboom D.J., Oberg K., Eriksson B., Wiedenmann B., Rindi G., O'Toole D., Ferone D., Ahlman H., Arnold R., Bechstein W.O., Cadiot G., Caplin M., Christ E., Chung D., Couvelard A., Delle F.G., Falchetti A., Goretzki P., Gross D., Hochhauser D., Hyrdel R., Jensen R., Kaltsas G., Kelestimur F., Kianmanesh R., Knapp W., Knigge U.P., Komminoth P., Korner M., Kos-Kudla B., Kvols L., Lewington V., Lopes J.M., Manfredi R
[5] De Herwer W.W., Van Schaik E., Kwekkeboom D., Feelders R.A., New therapeutic options for metastatic malignant insulinomas, Clin Endocrinol, 75, pp. 277-284, (2011)
[6] Benedetto L., Riccardo C., Valentina F., Yolanda Q., Hipolito D., Hipolito D., Et al., Giant pancreatic insulinoma. The bigger the worse? Report of two cases and literature review, Int J Surg Case Rep, 4, 4, pp. 265-268, (2013)
[7] Callacondo D., Arenas J.L., Ganoza A.J., Rojas-Camayo J., Quesada-Olarte J., Robledo H., Giant insulinoma: A report of 3 cases and review of the literature, Pancreas, 42, 8, pp. 1323-1332, (2013)
[8] Takamori H., Kanemitsu K., Tsuji T., Tanaka H., Chikamoto A., Nakahara O., Et al., 5-fluorouracil intra-arterial infusion combined with systematic gemcitabine for unresectable pancreatic cancer, Pancreas, 30, pp. 223-236, (2005)

← 1 →