Chronic kidney disease of unknown aetiology and ground-water ionicity: study based on Sri Lanka

被引：0

作者：

M. W. C. Dharma-wardana

Sarath L. Amarasiri

Nande Dharmawardene

C. R. Panabokke

机构：

[1] National Research Council,

[2] Universitë de Montreal,undefined

[3] Soil Science Society of Sri Lanka,undefined

[4] Bibile Sugar Industries,undefined

[5] International Water Management Institute,undefined

来源：

Environmental Geochemistry and Health | 2015年 / 37卷

关键词：

Kidney disease; Water quality; Electrolytes; Protein denaturing; Fertilizers; Soils; Aquifers; Sri Lanka;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

High incidence of chronic kidney disease of unknown aetiology (CKDU) in Sri Lanka is shown to correlate with the presence of irrigation works and rivers that bring-in ‘nonpoint source’ fertilizer runoff from intensely agricultural regions. We review previous attempts to link CKDU with As, Cd and other standard toxins. Those studies (e.g. the WHO-sponsored study), while providing a wealth of data, are inconclusive in regard to aetiology. Here, we present new proposals based on increased ionicity of drinking water due to fertilizer runoff into the river system, redox processes in the soil and features of ‘tank’-cascades and aquifers. The consequent chronic exposure to high ionicity in drinking water is proposed to debilitate the kidney via a Hofmeister-type (i.e. protein-denaturing) mechanism.

引用

页码：221 / 231

页数：10

共 114 条

[1]

Acquavella JF(2004)Glyphosate biomonitoring for farmers and their families: Results from the farm family exposure study Environmental Health Perspectives 112 321-326

[2]

Alexander BH(2013)Prevalence estimates of chronic kidney disease in Canada: Results of a nationally representative survey CMAJ 185 E417-E423

[3]

Mandel JS(1996)How hofmeister ion interactions affect protein stability iophysics Journal 71 2056-2063

[4]

Gustin C(2008)Chronic renal failure among farm families in cascade irrigation systems in Sri Lanka associated with elevated dietary cadmium levels in rice and freshwater fish (tilapia) Environmental Geochemistry and Health 30 465-478

[5]

Baker B(2011)Chronic kidney diseases of uncertain etiology in Sri Lanka: Geographic distribution and environmental implications Environmental Geochemistry and Health 33 267-278

[6]

Chapman P(2003)Drinking water quality in the Ethiopian section of the East African Rift valley I—data and health aspects The Science of the Total Environment 311 65-80

[7]

Bleeke M(2007)Prevalence of chronic kidney disease in the United States JAMA 298 2038-2047

[8]

Arora P(2009)Dissolution of aluminium from substandard utensils under high fluoride stress: A possible risk factor for chronic renal failures in the North-Central province Journal of the National Science Foundation of Sri Lanka 37 219-222

[9]

Vasa P(2012)Risk of lentil seed contamination by risk metals from the soil The Journal of Microbiology, Biotechnology and Food sciences 2 338-9

[10]

Brenner D(2013)Geographical distribution of chronic kidney disease of unknown origin in north central region of Sri Lanka Ceylon Medical Journal 58 6-73

← 1 2 3 4 5 6 7 8 9 10 →