RALA and RALBP1 regulate mitochondrial fission at mitosis

被引：0
|
作者：
David F. Kashatus
Kian-Huat Lim
Donita C. Brady
Nicole L. K. Pershing
Adrienne D. Cox
Christopher M. Counter
机构：
[1] Duke University Medical Center,Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
[2] Lineberger Comprehensive Cancer Center,Department of Pharmacology and Radiation Oncology
[3] University of North Carolina at Chapel Hill,undefined
[4] Present address: Medical Oncology Branch,undefined
[5] National Cancer Institute,undefined
[6] National Institutes of Health,undefined
[7] Bethesda,undefined
[8] Maryland 20892,undefined
[9] USA,undefined
来源：
Nature Cell Biology | 2011年 / 13卷
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学科分类号：
摘要：
Mitotic mitochondrial fission requires CDK1-mediated phosphorylation of DRP1. The Aurora A substrate RALA is found to concentrate DRP1 and RALBP1 at mitochondria to promote DRP1 phosphorylation and fission.
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页码：1108 / 1115
页数：7
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