RALA and RALBP1 regulate mitochondrial fission at mitosis

被引：0
|
作者：
David F. Kashatus
Kian-Huat Lim
Donita C. Brady
Nicole L. K. Pershing
Adrienne D. Cox
Christopher M. Counter
机构：
[1] Duke University Medical Center,Department of Pharmacology and Cancer Biology, Department of Radiation Oncology
[2] Lineberger Comprehensive Cancer Center,Department of Pharmacology and Radiation Oncology
[3] University of North Carolina at Chapel Hill,undefined
[4] Present address: Medical Oncology Branch,undefined
[5] National Cancer Institute,undefined
[6] National Institutes of Health,undefined
[7] Bethesda,undefined
[8] Maryland 20892,undefined
[9] USA,undefined
来源：
Nature Cell Biology | 2011年 / 13卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mitotic mitochondrial fission requires CDK1-mediated phosphorylation of DRP1. The Aurora A substrate RALA is found to concentrate DRP1 and RALBP1 at mitochondria to promote DRP1 phosphorylation and fission.
引用
收藏
页码：1108 / 1115
页数：7
相关论文
共 50 条
  • [1] RALA and RALBP1 regulate mitochondrial fission at mitosis
    Kashatus, David F.
    Lim, Kian-Huat
    Brady, Donita C.
    Pershing, Nicole L. K.
    Cox, Adrienne D.
    Counter, Christopher M.
    NATURE CELL BIOLOGY, 2011, 13 (09) : 1108 - U138
  • [2] RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease
    Awasthi, Sanjay
    Hindle, Ashly
    Sawant, Neha A.
    George, Mathew
    Vijayan, Murali
    Kshirsagar, Sudhir
    Morton, Hallie
    Bunquin, Lloyd E.
    Palade, Philip T.
    Lawrence, J. Josh
    Khan, Hafiz
    Bose, Chhanda
    Reddy, P. Hemachandra
    Singh, Sharda P.
    CELLS, 2021, 10 (11)
  • [3] Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD
    Han, Kihoon
    Kim, Myoung-Hwan
    Seeburg, Daniel
    Seo, Jinsoo
    Verpelli, Chiara
    Han, Seungnam
    Chung, Hye Sun
    Ko, Jaewon
    Lee, Hyun Woo
    Kim, Karam
    Heo, Won Do
    Meyer, Tobias
    Kim, Hyun
    Sala, Carlo
    Choi, Se-Young
    Sheng, Morgan
    Kim, Eunjoon
    PLOS BIOLOGY, 2009, 7 (09)
  • [4] RalBP1, a novel approach for ovarian cancer therapy
    Singhal, Sharad S.
    Ramisetty, Sravani
    Mohanty, Atish
    Kulkarni, Prakash
    Horne, David
    Awasthi, Sanjay
    Salgia, Ravi
    CANCER RESEARCH, 2024, 84 (06)
  • [5] RALBP1/RLIP76 mediates multidrug resistance
    Drake, Kenneth J.
    Singhal, Jyotsana
    Yadav, Sushma
    Nadkar, Aalok
    Pungaliya, Chirag
    Singhal, Sharad S.
    Awasthi, Sanjay
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2007, 30 (01) : 139 - 144
  • [6] RalBP1 Is Necessary for Metastasis of Human Cancer Cell Lines
    Wu, Zhong
    Owens, Charles
    Chandra, Nidhi
    Popovic, Kay
    Conaway, Mark
    Theodorescu, Dan
    NEOPLASIA, 2010, 12 (12): : 1003 - 1012
  • [7] Haploinsufficiency Interactions of RALBP1 and TP53 in Carcinogenesis
    Awasthi, Sanjay
    CANCERS, 2021, 13 (02)
  • [8] Rat RalBP1 is an ATP-dependent transporter of organic anions
    Swatko, ME
    Cheng, JZ
    Singhal, SS
    Awasthi, YC
    Awasthi, S
    Zimniak, P
    CHEMICO-BIOLOGICAL INTERACTIONS, 2001, 133 (1-3) : 249 - 255
  • [9] Partial RALBP1 loss depletes DNA repair pathway genes
    Awasthi, Sanjay
    Bose, Chhanda
    Jones, Catherine
    Rahman, Rakhshanda
    Singhal, Sharad S.
    Singh, Sharda P.
    CANCER RESEARCH, 2020, 80 (04)
  • [10] Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module
    Wang, Shifeng
    Chen, Xu
    Crisman, Lauren
    Dou, Ximing
    Winborn, Christina S.
    Wan, Chun
    Puscher, Harrison
    Yin, Qian
    Kennedy, Matthew J.
    Shen, Jingshi
    SCIENCE ADVANCES, 2023, 9 (08)
12345