Bone Loss in Rheumatoid Arthritis: Systemic, Periarticular, and Focal

被引：0
作者：
Chad Deal
机构：
[1] University School of Medicine,Center for Osteoporosis and Metabolic Bone Disease, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine at Case Western
[2] University School of Medicine,Orthopaedic and Rheumatologic Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine at Case Western
来源：
Current Rheumatology Reports | 2012年 / 14卷
关键词：
Osteoporosis; FRAX; Periarticular osteopenia; Marginal erosions; Wnt signaling; RANK ligand; Inflammation; Osteoimmunology; Osteoblasts; Osteoclasts; Magnetic resonance imaging; MRI; Bone loss; Rheumatoid arthritis; Systemic; Periarticular; Focal;
D O I：
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学科分类号：
摘要：
Rheumatoid arthritis is a chronic inflammatory disease that results in generalized bone loss and increased fracture risk. Characteristic radiologic features of rheumatoid arthritis include periarticular osteopenia and marginal erosions. An emerging literature highlights the importance of osteoclasts as mediators of the erosive process, with an impairment of bone formation by inhibition of the Wnt signaling pathway as a cause of lack of repair of erosions. MRI has demonstrated the importance of inflammation in the bone marrow compartment as a cause of periarticular osteopenia. The term osteoimmunology has evolved to highlight the association between cells and cytokines of the immune system and their relationship to bone metabolism in rheumatoid arthritis and other forms of chronic inflammatory arthritis.
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页码：231 / 237
页数：6
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