Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits

被引:0
作者
Benjamin S. Glicksberg
Letizia Amadori
Nicholas K. Akers
Katyayani Sukhavasi
Oscar Franzén
Li Li
Gillian M. Belbin
Kristin L. Akers
Khader Shameer
Marcus A. Badgeley
Kipp W. Johnson
Ben Readhead
Bruce J. Darrow
Eimear E. Kenny
Christer Betsholtz
Raili Ermel
Josefin Skogsberg
Arno Ruusalepp
Eric E. Schadt
Joel T. Dudley
Hongxia Ren
Jason C. Kovacic
Chiara Giannarelli
Shuyu D. Li
Johan L. M. Björkegren
Rong Chen
机构
[1] Icahn School of Medicine at Mount Sinai,Department of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology
[2] Icahn School of Medicine at Mount Sinai,The Institute for Next Generation Healthcare
[3] Cardiovascular Research Center and Cardiovascular Institute,Department of Pathophysiology, Institute of Biomedicine and Translation Medicine
[4] Icahn School of Medicine at Mount Sinai,Department of Cardiac Surgery
[5] University of Tartu,Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet
[6] Biomeedikum,Department of Pediatrics, Herman B Wells Center for Pediatric Research, Center for Diabetes and Metabolic Diseases, Stark Neurosciences Research Institute
[7] Clinical Gene Networks AB,Bakar Computational Health Sciences Institute
[8] Charles Bronfman Institute of Personalized Medicine,undefined
[9] Icahn School of Medicine at Mount Sinai,undefined
[10] Sema4,undefined
[11] a Mount Sinai venture,undefined
[12] Department of Preventive Medicine,undefined
[13] Icahn School of Medicine at Mount Sinai,undefined
[14] Department of Immunology,undefined
[15] Genetics and Pathology,undefined
[16] Tartu University Hospital,undefined
[17] Karolinska Universitetssjukhuset Huddinge,undefined
[18] Department of Health Policy and Research,undefined
[19] Icahn School of Medicine at Mount Sinai,undefined
[20] Indiana University,undefined
[21] University of California San Francisco,undefined
[22] Integrated Cardio Metabolic Centre,undefined
[23] Department of Medicine,undefined
[24] Karolinska Institutet,undefined
[25] Novum,undefined
来源
BMC Medical Genomics | / 12卷
关键词
Loss-of-function variant; Cardiovascular traits; Genetic association; Integrative data analysis; Target identification and validation; Electronic Medical Records;
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