Quantification of aortic stiffness in stroke patients using 4D flow MRI in comparison with transesophageal echocardiography

被引:0
作者
Thomas Wehrum
Felix Günther
Miriam Kams
Sarah Wendel
Christoph Strecker
Hanieh Mirzaee
Andreas Harloff
机构
[1] University of Freiburg,Department of Neurology and Clinical Neurophysiology, Medical Center – University of Freiburg, Faculty of Medicine
[2] University of Freiburg,Department of Cardiology and Angiology, Medical Center – University of Freiburg, Faculty of Medicine
[3] Fraunhofer Mevis,undefined
来源
The International Journal of Cardiovascular Imaging | 2018年 / 34卷
关键词
Aorta; Stiffness; Compliance; PWV; TEE; 4D flow MRI;
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学科分类号
摘要
To quantify stiffness of the descending aorta (DAo) in stroke patients using 4D flow MRI and compare results with transesophageal echocardiography (TEE). 48 acute stroke patients undergoing 4D flow MRI and TEE were included. Intima-media-thickness (IMT) was measured in the DAo and the aorta was scrutinized for atherosclerotic plaques using TEE. Stiffness of the DAo was determined by (a) 4D flow MRI at 3 T by calculating pulse wave velocity (PWV) and by (b) TEE calculating arterial strain, stiffness index, and distensibility coefficient. Mean IMT was 1.43 ± 1.75. 7 (14.6%) subjects had no sign of atherosclerosis, 10 (20.8%) had IMT-thickening or plaques < 4 mm, and 31 (66.7%) had at least one large and/or complex plaque in the aorta. Increased IMT significantly correlated (p < 0.001) with increased DAo stiffness in MRI (PWV r = 0.66) and in TEE (strain r = 0.57, stiffness index r = 0.64, distensibility coefficient r = 0.57). Patients with at least IMT-thickening had significantly higher stiffness values compared to patients without atherosclerosis. However, no difference was observed between patients with plaques < 4 mm and patients with plaques ≥ 4 mm. PWV and TEE parameters of stiffness correlated significantly [strain (r = − 0.36; p = 0.011), stiffness index (r = 0.51; p = 0.002), and distensibility coefficient (r = − 0.59; p < 0.001)]. 4D flow MRI and TEE-based parameters of aortic stiffness were associated with markers of atherosclerosis such as IMT-thickness and presence of plaques. We believe that 4D flow MRI is a promising tool for future studies of aortic atherosclerosis, due to its longer coverage of the aorta and non-invasiveness.
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页码:1629 / 1636
页数:7
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