Neuronal Correlates of Brain-derived Neurotrophic Factor Val66Met Polymorphism and Morphometric Abnormalities in Bipolar Disorder

被引:0
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作者
Koji Matsuo
Consuelo Walss-Bass
Fabiano G Nery
Mark A Nicoletti
John P Hatch
Benicio N Frey
Emel S Monkul
Giovana B Zunta-Soares
Charles L Bowden
Michael A Escamilla
Jair C Soares
机构
[1] The University of Texas Health Science Center,Department of Psychiatry
[2] Yamaguchi University Graduate School of Medicine,Division of Neuropsychiatry, Department of Neuroscience
[3] Bipolar Disorder Research Program (PROMAN),Department of Psychiatry
[4] Institute of Psychiatry,Department of Psychiatry
[5] University of Sao Paulo Medical School,Department of Orthodontics
[6] University of North Carolina,Department of Psychiatry and Behavioural Neurosciences
[7] Center of Excellence for Research and Treatment of Bipolar Disorder (CERT-BD),Department of Cellular and Structural Biology
[8] University of North Carolina,undefined
[9] The University of Texas Health Science Center,undefined
[10] McMaster University,undefined
[11] University of Texas Health Science Center,undefined
来源
Neuropsychopharmacology | 2009年 / 34卷
关键词
bipolar disorder; BDNF; cingulate cortex; voxel-based morphometry; memory; gray matter;
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学科分类号
摘要
The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has been proposed as a possible candidate for involvement in the pathophysiology of bipolar disorder (BD). To determine whether an association exists between the BDNF Val66Met genotype and morphometric abnormalities of the brain regions involved in memory and learning in BD and healthy subjects. Forty-two BD patients and 42 healthy subjects were studied. Interactions between BDNF Val66Met genotype and diagnosis in gray (GM) volumes were analyzed using an optimized voxel-based morphometry technique. Declarative memory function was assessed with the California Verbal Learning Test II. Left and right anterior cingulate GM volumes showed a significant interaction between genotype and diagnosis such that anterior cingulate GM volumes were significantly smaller in the Val/Met BD patients compared with the Val/Val BD patients (left P=0.01, right P=0.01). Within-group comparisons revealed that the Val/Met carriers showed smaller GM volumes of the dorsolateral prefrontal cortex compared with the Val/Val subjects within the BD patient (P=0.01) and healthy groups (left P=0.03, right P=0.03). The Val/Met healthy subjects had smaller GM volumes of the left hippocampus compared with the Val/Val healthy subjects (P<0.01). There was a significant main effect of diagnosis on memory function (P=0.04), but no interaction between diagnosis and genotype was found (P=0.48). The findings support an association between the BDNF Val66Met genotype and differential gray matter content in brain structures, and suggest that the variation in this gene may play a more prominent role in brain structure differences in subjects affected with BD.
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页码:1904 / 1913
页数:9
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