Role of COMT in ADHD: a Systematic Meta-Analysis

被引：0
作者：
Hongjuan Sun
Fangfen Yuan
Xuemei Shen
Guanglian Xiong
Jing Wu
机构：
[1] Huazhong University of Science and Technology,Key Laboratory of Environment and Health, Ministry of Education & Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College
来源：
Molecular Neurobiology | 2014年 / 49卷
关键词：
ADHD; COMT; Meta-analysis;
D O I：
暂无
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学科分类号：
摘要：
Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable childhood-onset psychiatric disorder with significant genetic contribution. Considerable evidence has implicated involvement of dopaminergic system and the prefrontal cortex (PFC) in the pathomechanism of ADHD. The catechol-O-methyltransferase (COMT) gene is of particular interest for ADHD as its crucial role in the degradation of dopamine in the PFC. We summarized the reported findings investigating associations between COMT gene and ADHD and performed a meta-analysis of previous studies to assess the overall magnitude and significance of the association.
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页码：251 / 261
页数：10
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