Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats

被引：0
作者：
Yu Deng
Xing Tan
Miao-Ling Li
Wei-Zhong Wang
Yang-Kai Wang
机构：
[1] Second Military Medical University,Department of Physiology
[2] Second Military Medical University,Institution of Polar Medicine Research Center
[3] Changhai Hospital,Department of Anesthesiology
[4] Southwest Medical University,Institute of Cardiovascular Medical Research
来源：
Neuroscience Bulletin | 2019年 / 35卷
关键词：
Hypertension; Renin-angiotensin system; Gene transfer; Acetylcholine; Sympathetic nerve activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The rostral ventrolateral medulla (RVLM) is a key region in cardiovascular regulation. It has been demonstrated that cholinergic synaptic transmission in the RVLM is enhanced in hypertensive rats. Angiotensin-converting enzyme 2 (ACE2) in the brain plays beneficial roles in cardiovascular function in hypertension. The purpose of this study was to determine the effect of ACE2 overexpression in the RVLM on cholinergic synaptic transmission in spontaneously hypertensive rats (SHRs). Four weeks after injecting lentiviral particles containing enhanced green fluorescent protein and ACE2 bilaterally into the RVLM, the blood pressure and heart rate were notably decreased. ACE2 overexpression significantly reduced the concentration of acetylcholine in microdialysis fluid from the RVLM and blunted the decrease in blood pressure evoked by bilateral injection of atropine into the RVLM in SHRs. In conclusion, we suggest that ACE2 overexpression in the RVLM attenuates the enhanced cholinergic synaptic transmission in SHRs.
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页码：67 / 78
页数：11
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