Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats

被引：0
作者：
Yu Deng
Xing Tan
Miao-Ling Li
Wei-Zhong Wang
Yang-Kai Wang
机构：
[1] Second Military Medical University,Department of Physiology
[2] Second Military Medical University,Institution of Polar Medicine Research Center
[3] Changhai Hospital,Department of Anesthesiology
[4] Southwest Medical University,Institute of Cardiovascular Medical Research
来源：
Neuroscience Bulletin | 2019年 / 35卷
关键词：
Hypertension; Renin-angiotensin system; Gene transfer; Acetylcholine; Sympathetic nerve activity;
D O I：
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学科分类号：
摘要：
The rostral ventrolateral medulla (RVLM) is a key region in cardiovascular regulation. It has been demonstrated that cholinergic synaptic transmission in the RVLM is enhanced in hypertensive rats. Angiotensin-converting enzyme 2 (ACE2) in the brain plays beneficial roles in cardiovascular function in hypertension. The purpose of this study was to determine the effect of ACE2 overexpression in the RVLM on cholinergic synaptic transmission in spontaneously hypertensive rats (SHRs). Four weeks after injecting lentiviral particles containing enhanced green fluorescent protein and ACE2 bilaterally into the RVLM, the blood pressure and heart rate were notably decreased. ACE2 overexpression significantly reduced the concentration of acetylcholine in microdialysis fluid from the RVLM and blunted the decrease in blood pressure evoked by bilateral injection of atropine into the RVLM in SHRs. In conclusion, we suggest that ACE2 overexpression in the RVLM attenuates the enhanced cholinergic synaptic transmission in SHRs.
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页码：67 / 78
页数：11
相关论文
共 267 条
[1]  
Wang JG(2018)Global impact of 2017 American College of Cardiology/American Heart Association Hypertension Guidelines: a perspective from China Circulation 137 546-548
[2]  
Liu L(2016)Update in hypertension therapy Med Clin North Am 100 665-693
[3]  
Mankin LA(2010)Sympathetic nervous system overactivity and its role in the development of cardiovascular disease Physiol Rev 90 513-557
[4]  
Malpas SC(2006)The sympathetic control of blood pressure Nat Rev Neurosci 7 335-346
[5]  
Guyenet PG(2003)Brainstem mechanisms of hypertension: role of the rostral ventrolateral medulla Curr Hypertens Rep 5 262-268
[6]  
Sved AF(2011)Angiotensin peptides and central autonomic regulation Curr Opin Pharmacol 11 131-137
[7]  
Ito S(2014)Brain stem NOS and ROS in neural mechanisms of hypertension Antioxid Redox Signal 20 146-163
[8]  
Sved JC(1981)Central cardiovascular effects of physostigmine in the cat; possible cholinergic aspects of blood pressure regulation Arch Int Pharmacodyn Ther 253 22-39
[9]  
Diz DI(1989)Cholinergic regulation of arterial pressure by the C1 area of the rostral ventrolateral medulla J Neurosci 9 923-942
[10]  
Arnold AC(1982)Cardiovascular control by cholinergic mechanisms in the central nervous system Annu Rev Pharmacol Toxicol 22 341-381
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