Inhibition of thiopurine S-methyltransferase activity by impurities in commercially available substrates: a factor for differing results of TPMT measurements

被引：0

作者：

T. Kröplin

C. Fischer

H. Iven

机构：

[1] Department of Pharmacology,

[2] Lübeck Medical University,undefined

[3] Ratzeburger Allee 160,undefined

[4] D-23538 Lübeck,undefined

[5] Germany Tel.: +49-451-500-2682; Fax: +49-451-500-2686,undefined

[6] Dr. Fischer Bosch Institute of Clinical Pharmacology,undefined

[7] Stuttgart,undefined

[8] Germany,undefined

来源：

European Journal of Clinical Pharmacology | 1999年 / 55卷

关键词：

Key words Thiopurine methyltransferase polymorphism;

D O I：

暂无

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学科分类号：

摘要：

Objectives: Thiopurine S-methyltransferase (TPMT) activity, when measured in red blood cells (RBC) with a recently published TPMT activity assay using 6‐thioguanine (6-TG) as substrate, could not be reproduced in another laboratory. We investigated factors which could influence the results of the TPMT activity measurement.

引用

页码：285 / 291

页数：6