Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among Nigerian African stroke survivors

被引：22
作者：
Akinyemi R.O. [1 ,2 ]
Firbank M. [2 ]
Ogbole G.I. [3 ]
Allan L.M. [2 ]
Owolabi M.O. [4 ]
Akinyemi J.O. [5 ]
Yusuf B.P. [3 ]
Ogunseyinde O. [3 ]
Ogunniyi A. [4 ]
Kalaria R.N. [2 ]
机构：
[1] Division of Neurology, Department of Medicine, Federal Medical Centre Abeokuta, Abeokuta
[2] Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne
[3] Department of Radiology, University of Ibadan, Ibadan
[4] Department of Medicine, University of Ibadan, Ibadan
[5] Department of Epidemiology and Medical Statistics, University of Ibadan, Ibadan
来源：
BMC Research Notes | / 8卷 / 1期
关键词：
Africa; Brain atrophy; Dementia; Neuroimaging; Nigeria; Stroke; Vascular cognitive impairment; Vascular dementia;
D O I：
10.1186/s13104-015-1552-7
中图分类号：
学科分类号：
摘要：
Background: Neuroimaging features associated with vascular cognitive impairment have not been examined in sub-Saharan Africans. We determined magnetic resonance imaging (MRI) features associated with cognitive impairment in a sample of Nigerian stroke survivors. Methods: Stroke survivors underwent brain MRI with standardized assessment of brain volumes and visual rating of medial temporal lobe atrophy (MTA), and white matter hyperintensities (WMH) at 3 months post-stroke. Demographic, clinical and psychometric assessments of global cognitive function, executive function, mental speed and memory were related to changes in structural MRI. Results: In our pilot sample of 58 stroke survivors (60.1 ± 10.7 years old) MTA correlated significantly with age (r = 0.525), WMH (r = 0.461), memory (r = -0.702), executive function (r = -0.369) and general cognitive performance (r = -0.378). On univariate analysis, age >60 years (p = 0.016), low educational attainment (p < 0.001 to p < 0.003), total brain volume (p < 0.024 and p < 0.025) and MTA (p < 0.003 to p < 0.007) but not total WMH (p < 0.073, p = 0.610) were associated with cognitive outcome. In a two-step multivariate regression analysis, MTA (p < 0.035 and p < 0.016) and low educational attainment (p < 0.012 and p < 0.019) were sustained as independent statistical predictors of cognitive outcome. Conclusions: Medial temporal lobe atrophy was a significant neuroimaging predictor of early post-stroke cognitive dysfunction in the Nigerian African stroke survivors. These observations have implications for a vascular basis of MTA in older stroke survivors among sub-Saharan Africans. © 2015 Akinyemi et al.
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