To determine whether computed tomography perfusion imaging (CTPI)-derived parameters are associated with vascular cognitive impairment (VCI) in patients with transient ischemic attack (TIA). Patients with first-time anterior circulation TIA (diagnosed within 24 h of onset) and normal cognition, treated between August 2009 and August 2014 at the Department of Neurology of Chengdu Military General Hospital, China, were analyzed retrospectively. Patients underwent whole-brain CTPI within 1 week of TIA to detect cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP) in the ischemic region. Based on cognitive function assessment 4 weeks after TIA, using the Montreal cognitive assessment (MoCA) and mini mental state examination, the patients were divided into control and VCI groups. CTPI parameters and other clinical data were compared between groups, and Spearman’s correlation analysis used to identify associations between cognitive scores and CTPI parameters in the VCI group. 50 patients (25 per group; aged 55–72 years) were included. Patient age, gender, smoking status, alcohol consumption, educational level, time from TIA onset to admission, time from TIA onset to CTPI, and prevalence of hypertension, diabetes mellitus, hyperlipidemia, atrial fibrillation and hyperhomocysteinemia did not differ between groups. Both groups showed TTP and MTT prolongation, CBF reduction, but no change in CBV in the ischemic region; these changes were significantly larger in the VCI group (P < 0.05). MTT correlated negatively with MoCA score (r = −0.51, P = 0.009). CTPI could facilitate early diagnosis of VCI in patients with anterior circulation TIA.
机构:
Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
China Int Neurosci Inst China INI, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
Xu, Ran
Yang, Bin
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Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
China Int Neurosci Inst China INI, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
Yang, Bin
Wang, Tao
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Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
China Int Neurosci Inst China INI, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
Wang, Tao
Zhang, Xiao
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Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
China Int Neurosci Inst China INI, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
Zhang, Xiao
Li, Tianhua
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Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
China Int Neurosci Inst China INI, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
Li, Tianhua
Feng, Yao
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Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
China Int Neurosci Inst China INI, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
Feng, Yao
Guo, Xiaofan
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机构:
Loma Linda Univ Hlth, Dept Neurol, Loma Linda, CA USACapital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
Guo, Xiaofan
Jia, Jinzhu
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机构:
Peking Univ, Sch Publ Hlth, Beijing, Peoples R China
Peking Univ, Ctr Stat Sci, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
Jia, Jinzhu
Ma, Yan
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Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
China Int Neurosci Inst China INI, Beijing, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
Ma, Yan
Dmytriw, Adam A.
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机构:
Massachusetts Gen Hosp, Neuroendovasc Program, Boston, MA USA
Brigham & Womens Hosp, Neuroradiol & Neurointervent, Boston, MA USACapital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
Dmytriw, Adam A.
Jia, Haibo
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机构:
Harbin Med Univ, Affiliated Hosp 2, Dept Cardiol, Harbin, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
Jia, Haibo
Jiao, Liqun
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机构:
Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
China Int Neurosci Inst China INI, Beijing, Peoples R China
Capital Med Univ, Xuanwu Hosp, Dept Intervent Neuroradiol, Beijing, Peoples R China
Shandong First Med Univ, Jinan Hosp, Xuanwu Hosp, Dept Neurosurg & Neurol, Jinan, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China
机构:
Univ Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, EnglandUniv Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, England
Zamboni, Giovanna
Griffanti, Ludovica
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Univ Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, EnglandUniv Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, England
Griffanti, Ludovica
Jenkinson, Mark
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Univ Oxford, Oxford Ctr Funct MRI Brain FMRIB, Nuffield Dept Clin Neurosci, Oxford, EnglandUniv Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, England
Jenkinson, Mark
Mazzucco, Sara
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Univ Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, EnglandUniv Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, England
Mazzucco, Sara
Li, Linxin
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机构:
Univ Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, EnglandUniv Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, England
Li, Linxin
Kuker, Wilhelm
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机构:
Univ Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, EnglandUniv Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, England
Kuker, Wilhelm
Pendlebury, Sarah T.
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机构:
Univ Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, EnglandUniv Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, England
Pendlebury, Sarah T.
Rothwell, Peter M.
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机构:
Univ Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, EnglandUniv Oxford, Stroke Prevent Res Unit, Nuffield Dept Clin Neurosci, John Radcliffe Hosp, Oxford, England
机构:
Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
Zuo, L. J.
Dong, Y. H.
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机构:
Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore
Univ New South Wales, Sch Psychiat, Ctr Healthy Brain Ageing CHeBA, Sydney, NSW, AustraliaCapital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
Dong, Y. H.
Zhu, R. Y.
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Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
Zhu, R. Y.
Jin, Z.
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Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
Jin, Z.
Li, Z. X.
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机构:
Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
China Natl Clin Res Ctr Neurol Dis, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
Li, Z. X.
Wang, Y. L.
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机构:
China Natl Clin Res Ctr Neurol Dis, Beijing 100050, Peoples R China
Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Tiantan Clin Trial & Res Ctr, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
Wang, Y. L.
Zhao, X. Q.
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China Natl Clin Res Ctr Neurol Dis, Beijing 100050, Peoples R China
Capital Med Univ, Beijing Tiantan Hosp, Vasc Neurol, Dept Neurol, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
Zhao, X. Q.
Sachdev, Perminder
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机构:
Univ New South Wales, Sch Psychiat, Ctr Healthy Brain Ageing CHeBA, Sydney, NSW, Australia
Prince Wales Hosp, Neuropsychiat Inst, Sydney, NSW, AustraliaCapital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
Sachdev, Perminder
Zhang, W.
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机构:
China Natl Clin Res Ctr Neurol Dis, Beijing 100050, Peoples R China
Capital Med Univ, Dept Geriatr, Beijing Tiantan Hosp, Beijing 100050, Peoples R China
Beijing Inst Brain Disorders, Ctr Parkinson Dis, Beijing 100053, Peoples R China
Beijing Key Lab Parkinson Dis, Beijing 100053, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
Zhang, W.
Wang, Y. J.
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机构:
Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
China Natl Clin Res Ctr Neurol Dis, Beijing 100050, Peoples R China
Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Tiantan Clin Trial & Res Ctr, Beijing 100050, Peoples R China
Capital Med Univ, Beijing Tiantan Hosp, Vasc Neurol, Dept Neurol, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China
机构:
Capital Med Univ, Dept Internal Med, Beijing Tiantan Hosp, Beijing, Peoples R ChinaCapital Med Univ, Dept Geriatr, Beijing Tiantan Hosp, Beijing, Peoples R China
Zuo, L. J.
Zhu, R. Y.
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机构:
Capital Med Univ, Dept Internal Med, Beijing Tiantan Hosp, Beijing, Peoples R ChinaCapital Med Univ, Dept Geriatr, Beijing Tiantan Hosp, Beijing, Peoples R China
Zhu, R. Y.
Jin, C.
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机构:
Capital Med Univ, Dept Internal Med, Beijing Tiantan Hosp, Beijing, Peoples R ChinaCapital Med Univ, Dept Geriatr, Beijing Tiantan Hosp, Beijing, Peoples R China
Jin, C.
Zhang, W.
论文数: 0引用数: 0
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机构:
Capital Med Univ, Dept Geriatr, Beijing Tiantan Hosp, Beijing, Peoples R China
Capital Med Univ, Dept Internal Med, Beijing Tiantan Hosp, Beijing, Peoples R China
Natl Ctr Clin Res Neurol Dis, Beijing, Peoples R ChinaCapital Med Univ, Dept Geriatr, Beijing Tiantan Hosp, Beijing, Peoples R China
Zhang, W.
Wang, Y. J.
论文数: 0引用数: 0
h-index: 0
机构:
Capital Med Univ, Dept Internal Med, Beijing Tiantan Hosp, Beijing, Peoples R China
Natl Ctr Clin Res Neurol Dis, Beijing, Peoples R ChinaCapital Med Univ, Dept Geriatr, Beijing Tiantan Hosp, Beijing, Peoples R China
机构:
Cap Univ Med Sci, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R ChinaCap Univ Med Sci, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China
Mao, Wei
Yang, Jing
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机构:
Cap Univ Med Sci, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R ChinaCap Univ Med Sci, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China
Yang, Jing
Wang, Moli
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机构:
Cap Univ Med Sci, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R ChinaCap Univ Med Sci, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China
Wang, Moli
Wang, Yuping
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机构:
Cap Univ Med Sci, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R ChinaCap Univ Med Sci, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China
Wang, Yuping
Wang, Dequan
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机构:
Cap Univ Med Sci, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R ChinaCap Univ Med Sci, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China
Wang, Dequan
Zhu, Liping
论文数: 0引用数: 0
h-index: 0
机构:
Cap Univ Med Sci, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R ChinaCap Univ Med Sci, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China
Zhu, Liping
Jia, Jiangping
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机构:
Cap Univ Med Sci, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R ChinaCap Univ Med Sci, Dept Neurol, Xuanwu Hosp, Beijing 100053, Peoples R China