Mathematical Model of Cardiovascular and Metabolic Responses to Umbilical Cord Occlusions in Fetal Sheep

被引：0
作者：
Qiming Wang
Nathan Gold
Martin G. Frasch
Huaxiong Huang
Marc Thiriet
Xiaogang Wang
机构：
[1] York University,Department of Mathematics and Statistics
[2] CHU Sainte-Justine Research Center,Department of Obstetrics and Gynecology, Faculty of Medicine
[3] CHU Sainte-Justine Research Center,Department of Neurosciences, Faculty of Medicine
[4] Université de Montréal,Centre de Recherche en Reproduction Animale (CRRA)
[5] Sorbonne University,UPMC, Laboratoire Jacques
来源：
Bulletin of Mathematical Biology | 2015年 / 77卷
关键词：
Mathematical modeling; Fetal blood circulation; Fetal acidemia; Hemodynamics; Labor; Neural control; Sensitivity analysis;
D O I：
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中图分类号：
学科分类号：
摘要：
Fetal acidemia during labor is associated with an increased risk of brain injury and lasting neurological deficits. This is in part due to the repetitive occlusions of the umbilical cord (UCO) induced by uterine contractions. Whereas fetal heart rate (FHR) monitoring is widely used clinically, it fails to detect fetal acidemia. Hence, new approaches are needed for early detection of fetal acidemia during labor. We built a mathematical model of the UCO effects on FHR, mean arterial blood pressure (MABP), oxygenation and metabolism. Mimicking fetal experiments, our in silico model reproduces salient features of experimentally observed fetal cardiovascular and metabolic behavior including FHR overshoot, gradual MABP decrease and mixed metabolic and respiratory acidemia during UCO. Combined with statistical analysis, our model provides valuable insight into the labor-like fetal distress and guidance for refining FHR monitoring algorithms to improve detection of fetal acidemia and cardiovascular decompensation.
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页码：2264 / 2293
页数：29
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